Ablation of Ventricular Fibrillation by Accurate Targeting of Arrhythmogenic Regions (AVATAR)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01492764

Acronym

AVATAR

Enrollment

Registered

2011-12-15

Start date

2011-06-30

Completion date

2014-08-31

Last updated

2019-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventricular Tachyarrhythmias

Keywords

Ventricular Tachyarrhythmia, Ablation, Electrophysiology, Human, Mapping

Brief summary

This study will test the hypothesis that many human heart rhythm disorders are caused by small localized sources, where brief ablation may successfully eliminate the heart rhythm disorder.

Detailed description

The investigators will enroll patients with documented rapid heart rates from the bottom chambers of the heart (ventricular tachyarrhythmias). During electrophysiological study, the investigators will map the localized sources of these heart rhythm disorders. 1. The 'active' group will prospectively receive brief ablation at localized sources (Focal Impulse and Rotor Modulation, FIRM). 2. The control group will be a historical cohort who have received traditional ablation for this disorder. All patients will be followed for up to 1 year to ensure that they have no recurrent arrhythmias.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

21 Years to 90 Years

Healthy volunteers

Inclusion criteria

1. Documented ventricular tachyarrhythmias. 2. Undergoing clinically indicated EP study with ablation.

Exclusion criteria

1\. Unwillingness or inability to provide informed consent.

Design outcomes

Primary

Measure	Time frame	Description
reduction in ventricular tachyarrhythmias events	3 months	Using careful clinical monitoring, we will compare the burden of VT/VF after ablation (including FIRM) to the burden preceding ablation.
safety of ventricular basket mapping in patients undergoing ablation	1 month	To assess the incidence of adverse events arising from ablation using basket mapping in the ventricles. These include but are not limited to stroke, systemic thromboembolism, MI or acute coronary syndrome, groin complications, or death.

Countries

United States

Outcome results