Obesity
Conditions
Keywords
human brown adipose tissue activity, obesity, energy metabolism, adaptive thermogenesis
Brief summary
To evaluate the effect of vagus nerve stimulation for refractory epilepsy on the activity of human brown adipose tissue.
Interventions
OTHEREnabling and disabling VNS
No intervention
Sponsors
Maastricht University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Subjects treated with VNS for epilepsy, aged 18-65 years, with a Body Mass Index (BMI) ≤ 28 kg/m2.
Exclusion criteria
* Body Mass Index \> 28 kg/m2 * Daily epileptic insults. * Subjects that need 'Rapid Cycling' VNS to control their frequency of epileptic insults. * Psychological unstable subjects (as judged by the treating neurologist). * subjects with mental retardation (as judged by the treating neurologist). * subjects with severe behaviour disorders (as judged by the treating neurologist). * Pregnant subjects. * Subjects that previously underwent high dose radiation for diagnostic or therapeutic purposes (radiotherapy, high frequency CT-scans). * The use of the following medication is an exclusion criterium; * ß-blockers, * Ketogenic diet
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| human brown adipose tissue activity | baseline and 2 weeks after |
Countries
Netherlands
Contacts
Primary ContactGuy H. Vijgen, M.D.
Backup ContactWouter D. van Marken Lichtenbelt, PhD.
Outcome results
None listed