Postoperative Cognitive Functions
Conditions
Keywords
Dexmedetomidine, midazolam, remifentanil, mini-mental state examination, monitored anaesthesia care, cystoscopy, sedation
Brief summary
The aim of the study was to compare the effects of remifentanil-dexmedetomidine and remifentanil-midazolam with mini-mental state examination (MMSE) in monitored anesthesia care (MAC) patients undergoing cystoscopy.
Detailed description
Forty patients undergoing cystoscopy receiving remifentanil infusion of 0.05 microgram per kg-1 min-1 were randomized into two groups: Either dexmedetomidine 1 microgram per kg -1 (GroupD) or midazolam 0.2 mg kg-1h-1 (GroupM) were administered intravenously for the first 10 minutes. Subsequently anesthesia was maintained by using the bispectral index(BIS) as a continuous infusion of dexmedetomidine 0.2-0.7 microgram per kg-1h-1 or midazolam 0.05-0.15 mgkg-1h-1. Heart rate, mean arterial pressure, MMSE, sedation and the patient's and surgeon's satisfaction were determined.
Interventions
DRUGRemifentanil
IV infusion
DRUGMidazolam
IV infusion
Sponsors
Gazi University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients with indication of cystoscopy must be able to have sedation
Exclusion criteria
* hypersensitivity to drugs used * morbid obesity * coronary disease * diabetes mellitus and other endocrinologic diseases * pregnancy * psychomotor diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Degree of sedative efficiency | During cystoscopy procedure | Bispectral Index (BIS) was used. |
| Degree of cognitive functions | Postoperative 60 minutes | mini-mental state examination(MMSE) test was used. |
Countries
Turkey (Türkiye)
Outcome results
None listed