Skin Aging
Conditions
Keywords
Skin aging, fibroblasts, transplantation, autologous
Brief summary
The purpose of this study is to evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses.
Detailed description
\- Analytical prospective autocontrolled study
Interventions
PROCEDUREautologous fibroblasts grafts
Autologous cultured fibroblasts will be grafted in facial skin
Sponsors
Federal University of São Paulo
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Women, aged between 50 to 70 years with facial wrinkles (rhytides), * Fitzpatrick III skin type, and * Who had reached menopause at least 3 years before entering the study were eligible for participation.
Exclusion criteria
* Women with uncontrolled comorbid conditions, * Smokers, * Alcohol and corticosteroid users, * Who had undergone chemical peeling or skin filling in the face or neck at least 12 months prior to the study, * Who had a keloid scar, * Who scored below 18 on the Mini-Mental State Examination, * Who had any psychiatric disorder or those undergoing orthodontic treatment were excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regeneration of facial ectoderm | one year after the grafting of autologous fibroblasts. | To evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses. |
Outcome results
None listed