Sarcopenia
Conditions
Keywords
Exercise, Aging, Sarcopenia, Mitochondria
Brief summary
Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (\> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training. Hypotheses. 1. to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program 2. to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age 3. to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program 4. to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age
Interventions
BEHAVIORALEndurance exercise
Participants will perform 8-weeks of endurance exercise training. Participants will train 5 days per week for 60 min at 65% of VO2 peak.
BEHAVIORALResistance exercise
Participants will perform 8-weeks of resistance exercise training. Participants will train 4 days per week for \ 60 min. Two days will focus on lower body resistance training and two days will focus on upper body.
BEHAVIORALControl/Combined training
Participants will perform 8-weeks of no exercise (control), followed by 8-weeks of combined endurance and resistance training. Participants will endurance train 5 days per week for 30 min at 65% of VO2 peak and resistance train 4 days per week for 30 min.
Sponsors
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy * 18 to 30 or \>65 years * Males and Females
Exclusion criteria
* Regular Exercise Program * Smoking * Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders) * Drugs known to impair metabolic function (beta blockers, steroids) * Allergies to lidocaine * Physical disability that precludes exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skeletal Muscle Protein Synthesis | Measured at week 0 (baseline) and week 8 | The investigators will determine the change from baseline in skeletal muscle protein synthesis. Measurments will be performed at baseline and following 8 weeks of exercise training. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mitochondrial Function | Measured at week 0 (baseline) and week 8 | The investigators will determine the change from baseline in mitochondrial function. Measurments will be performed at baseline and following 8 weeks of exercise training. |
Countries
United States
Outcome results
None listed