Drug Usage
Conditions
Keywords
intubating conditions, propofol, remifentanil, topical lidocaine
Brief summary
When not using neuromuscular blocking agent, even at optimal dosage, target-controlled infusion (TCI) of propofol and remifentanil occasionally produce unsatisfactory intubating conditions. Therefore, the investigators evaluated that the effect of tracheal lidocaine on the intubating conditions for tracheal intubation during anesthesia induction of propofol and remifentanil TCI without neuromuscular blocking agent in day-case anesthesia.
Detailed description
Anesthesia was induced with propofol-remifentanil TCI with the effect-site concentration of 5μg/ml and 5ng/ml, respectively. After TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, following intubation was performed.
Interventions
DRUGlidocaine
3 ml of 4% lidocaine was instilled to larynx and trachea
DRUGnormal saline
3 ml of normal saline was instilled to larynx and trachea before endotracheal intubation
Sponsors
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA I, II patients undergoing general anesthesia for reduction of nasal bone fracture
Exclusion criteria
* bronchial asthma, * COPD, * hypertension, * anticipated difficult airway
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall acceptable conditions for tracheal intubation | baseline from 5 min of TCI was maintained | Four minutes after start of propofol-remifentanil TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, and one minute later, intubation was performed in double-blinded fashion. |
Countries
South Korea
Outcome results
None listed