AVM, Brain Tumor, ICH
Conditions
Brief summary
The purpose of this study is to estimate the EC90 of remifentanil blunting hemodynamic changes to head fixation in the patients undergoing neurosurgery.
Interventions
DRUGremifentanil
According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during head fixation. And, For this allocation of dose of remifentanil the investigators use biased coin design up-and-down method. For the first patient, the dose of remifentanil would be fixed at 5.5ng/ml which we predict as EC90. And, step size of dose is 0.5ng/ml.
Sponsors
Seoul National University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing neurosurgery that require head fixation with mayfield head holder * patients who agree to our study
Exclusion criteria
* patients who don't agree to our study * BMI\<16.0 or BMI\>30 * cardiovascular disease, pulmonary disease, renal disease * alcoholic abuser or drug abuser * patients who takes any drug having an influence on cardiovascular system or sympathetic nervous system * any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction to peri-fixation period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mean arterial blood pressure | peri-fixation periord | mean arterial blood pressure will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation. |
| heart rate | peri-fixation periord | heart rate will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation. |
Countries
South Korea
Outcome results
None listed