Cetuximab and Dasatinib in Recurrent Squamous Cell Carcinoma

Inclusion criteria

Inclusion: * Patients must have metastatic and/or recurrent SCCHN that has been previously treated with cetuximab. * Undetectable baseline serum IL-6 NOTE : This eligibility criterion applies only to patients enrolling to the second, biomarker-enrichment stage of the trial. * Measurable disease per RECIST 1.1. * Unlimited prior treatment with radiation or chemoradiotherapy * Any number of prior regimens for recurrent or metastatic SCCHN (i.e. palliative treatment) including cetuximab or other EGFR inhibitor * Age \>18 years * ECOG performance status \<2 (Karnofsky \>60%, see Appendix A). * Life expectancy of greater than 12 weeks. * Patients must have normal organ and marrow function as defined below: 1. absolute neutrophil count \>1,200/µL 2. platelets \>100,000/µL 3. total bilirubin within normal institutional limits 4. AST(SGOT)/ALT(SGPT) \< 2.5 X institutional upper limit of normal 5. Creatinine up to 1.5 X normal institutional limits * Ability to understand and the willingness to sign a written informed Consent document. * Patients should not be taking concomitant medication that are CYP3A4 inducers or potent inhibitors and should try to avoid taking proton pump inhibitors and H2 antagonists during rest of treatment period. The above medications will be continued only if medically necessary and their use will be noted. * Sexually active women of childbearing potential must use an effective method of birth control during the course of the study, in a manner such that risk of failure is minimized. Prior to study enrollment, women of childbearing potential (WOCBP) must be advised of the importance of avoiding pregnancy during trial participation and the potential risk factors for an unintentional pregnancy. In addition, men enrolled on this study should understand the risks to any sexual partner of childbearing potential and should practice an effective method of birth control. All WOCBP MUST have a negative pregnancy test prior to first receiving investigational product. If the pregnancy test is positive, the patient must not receive investigational product and must not be enrolled in the study. In addition, all WOCBP should be instructed to contact the Investigator immediately if they suspect they might be pregnant (e.g., missed or late menstrual period) at any time during study participation. Exclusion: * Patients who have not recovered from adverse events due to prior agents. A minimum interval of 3 weeks should have elapsed from prior chemotherapy other than cetuximab. A minimum of 12 weeks should have elapsed from prior definitive radiotherapy, and a minimum of 1 week should have elapsed from prior palliative radiotherapy. * Patients may not have received an investigational agent within 4 weeks of starting this trial. * Patients with untreated brain metastases should be excluded from this clinical trial. * History of allergic reactions to monoclonal antibodies. * Inability to swallow oral medications (unless patients use a feeding tube in which case they are eligible). * Uncontrolled angina or uncontrolled hypertension or any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes). * Prolonged QTc interval on pre-entry electrocardiogram (\> 450 msec) on the Bazett's correction. * Diagnosed or suspected congenital long QT syndrome. * Patients currently taking drugs that are generally accepted to have a risk of causing Torsades de Pointes including: quinidine, procainamide, disopyramide, amiodarone, sotalol, ibutilide, dofetilide, erythromycins, clarithromycin, chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide, cisapride, bepridil, droperidol, methadone, arsenic, chloroquine, domperidone, halofantrine, levomethadyl, pentamidine, sparfloxacin, lidoflazine. * Any other uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, or psychiatric illness/social situations that would limit compliance with study requirements. * History of significant bleeding disorder unrelated to cancer, including: diagnosed congenital bleeding disorders (e.g., von Willebrand's disease), diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies).