Preterm Birth
Conditions
Brief summary
The purpose of this study is to investigate whether early life exposures such as premature birth or exposure to preeclampsia before you are born results in long-term alterations in the cardiovascular system that increase risk of cardiovascular disease development.
Detailed description
While the incidence of cardiovascular disease has reduced dramatically, coinciding with favourable changes in risk factors, cardiovascular disease remains the single largest cause of mortality and premature mortality in the United Kingdom. Identification of novel biological pathways that underlie disease susceptibility raises the potential for new early primary prevention strategies to complement classical management. There is particular interest in the role of early environment in 'programming' risk of cardiovascular disease in later life and growing evidence that various early life exposures impact cardiovascular health in the longer term. We have thus designed the Early Vascular Study to investigate the long-term impact of early life exposures, with a particular focus on the impact of preterm birth, in the presence or absence of pregnancy-induced hypertension in the mother, on the cardiovascular system in young adulthood. This study also allows investigation of the long term impact of perinatal interventions used in this cohort. Comprehensive multi-modality non-invasive imaging measures of cardiovascular structure and function allow precise quantification of cardiovascular phenotype. This is combined with blood sample collection to study changes in molecular and metabolic markers and pathways.
Interventions
None listed
Sponsors
University of Oxford
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Participant is willing and able to give informed consent for participation in the study. * Preterm-born Cohort: Born premature (\<37 weeks completed gestation), originally recruited as part of a randomised feeding trial at birth from one of five United Kingdom centres between 1982 and 1985. * Term-born Cohort: Born at term (\>37 weeks completed gestation) with normal birth weight for gestational age. * Able (in the Investigator's opinion) and willing to comply with all study requirements.
Exclusion criteria
-The participant may not enter the study if ANY of the following apply: * Unwilling or unable to give informed consent for participation in the study. * Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study. * Contraindication to Cardiovascular Magnetic Resonance Imaging.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac structure | Young adulthood | Left ventricular mass |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac function | Young adulthood | Global longitudinal strain and diastolic strain rate |
| Arterial stiffness | Young adulthood | Pulse wave velocity |
| Microvascular structure | Young adulthood | Capillary density |
| Cardiac structure | Young Adulthood | Right ventricular mass |
Countries
United Kingdom
Outcome results
None listed