Renal Transplant Surgery
Conditions
Keywords
Renal transplant surgery, hemodynamic management, PiCCO, delayed graft function
Brief summary
This study is designed to compare the incidence of delayed graft function in patients following renal transplant surgery with different perioperative hemodynamic managements: a goal directed hemodynamic management group (using PiCCO) and a control group.
Detailed description
Volume assessment and management during renal transplantation is one of the most challenging problems the anesthetist has to deal with. It seems sensible that individualized volume management and hydration therapy during the operation and during the stay at the intensive care unit could improve perfusion of the transplanted organ resulting in a better transplant function. Aim of this study is to investigate the impact of a goal directed hemodynamic management on incidence of delayed graft function (DGF) after renal transplant surgery. Therefore patients will be randomized in one of two groups, the PiCCO group with goal directed hemodynamic management during operation and during the ICU-stay and the control group with hemodynamic management performed according to heart rate, blood pressure and central venous pressure.
Interventions
DEVICEPiCCO® Monitoring
Fluid and vasopressor management according to PiCCO measurements
Sponsors
Technical University of Munich
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Renal Transplant Surgery * Age ≥ 65 years * Written informed consent
Exclusion criteria
* Contraindications for an arterial line in the femoral artery: * stents * bypasses * severe peripheral artery occlusive disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| delayed graft function | Start of anesthesia until day 7 after the operation |
Countries
Germany
Outcome results
None listed