Elderly
Conditions
Brief summary
The objective of this study is to verify changes in protein metabolism after ingesting a oral medical nutritional supplement.
Interventions
OTHEROral medical nutritional supplement
orally over a three hour period
OTHERExperimental oral medical nutritional supplement with AN777
orally over a three hour period
Sponsors
Abbott Nutrition
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
60 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and is ≥ 60 and ≤ 90 years of age. * Body Mass Index (BMI) \> 20.0, but \< 35.0. * Ability to climb a flight of 10 stairs or walk an equivalent of city block without help within the 3 months prior to enrollment. * Refrain from taking any dose of NSAIDs or acetaminophen on the day of and 24 hours prior to Visit 2 and Visit 3. * Refrain from using any pulmonary maintenance medications on the days of Visit 2 and Visit * Refrain from intense physical activity between visits.
Exclusion criteria
* Systemic corticosteroids within the 3 months prior to enrollment. * Blood thinner or anticoagulant medication within 1 week prior to enrollment. * Glomerular filtration rate (eGFR) of \< 40 mL/min/1.73m2. * Antibiotics within 1 week prior to enrollment. * Major surgery less than 3 months prior to enrollment in the study. * Active malignant disease or treated within the last 6 months for cancer. * Immunodeficiency disorder. * Diabetes * Myocardial infarction 3 months prior to enrollment. * Chronic obstructive pulmonary disease * History of allergy to any of the ingredients in the study products. * Conditions precluding ingestion or absorption of the study product, inflammatory bowel disease, short bowel syndrome, or other major gastrointestinal disease. * Dementia, brain metastases, eating disorders, history of significant neurological or psychiatric disorder, or any other psychological condition. * Pursuing weight loss or weight gain. * Medications/dietary supplements/substances that could modulate metabolism or weight.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in protein metabolism | Between baseline and 8 hours later | Via amino acid tracers |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intracellular signaling pathway metabolism | Between Baseline and 8 hours later | Via Amino acid tracers and protein phosphorylation measurements |
Countries
United States
Outcome results
None listed