Obsessive-Compulsive Disorder
Conditions
Brief summary
Cognitive behavior therapy is the most effective treatment of obsessive-compulsive disorder. However, the majority of treated patients remain symptomatic. The metacognitive therapy by Wells (1997) could achieve substantial gains in first pilot studies. The purpose of this study is to investigate this approach with a randomized controlled trial by comparing metacognitive therapy with exposure and response prevention for obsessive-compulsive disorder.
Interventions
BEHAVIORALMetacognitive Therapy
Metacognitive Therapy for OCD according to Wells (1997)
BEHAVIORALExposure and Response Prevention
Exposure and Response Prevention for OCD according to Kozak & Foa (1997)
Sponsors
Psychotherapie-Ambulanz Marburg e.V.
Philipps University Marburg
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Primary diagnosis: obsessive-compulsive disorder * German-speaking * Agreeing to participate, verified by completion of informed consent
Exclusion criteria
* Current or past diagnosis of substance dependence, psychosis, neurological conditions * Mental retardation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Symptom Severity (Yale Brown Obsessive-Compulsive Scale; YBOCS) from Pretest to Posttest to Follow-up | from Pretest (admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Metacognitions from Pretest to two in-between timepoints to Posttest to Follow-up | from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) | Metacognitions (MCQ), Thought Fusion Inventory (TFI), Thought Action Fusion Scale (TAF-scale), Beliefs About Rituals Inventory (BARI), Stop Signals Questionnaire (SSQ), Detached Mindfulness Questionnaire (DMQ) |
| Change in Obsessive Beliefs (Obsessive-Beliefs Questionnaire, OBQ) from Pretest to two in-between timepoints to Posttest to Follow-up | from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) | — |
| Change in Behavioral Avoidance (Behavioral Avoidance Test, BAT) from Pretest to two in-between timepoints to Posttest to Follow-up | from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) | — |
| Change in Depression (Beck Depression Inventory, BDI) from Pretest to Posttest to Follow-up | from Pretest (admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) | — |
| Change in Anxiety (Beck Anxiety Inventory, BAI) from Pretest to Posttest to Follow-up | from Pretest (admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) | — |
| Change in Symptom Severity (Padua Inventory; PI) from Pretest to two in-between timepoints to Posttest to Follow-up | from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) | — |
| Change in Symptom Severity (Clinical Global Impressions; CGI) from Pretest to two in-between timepoints to Posttest to Follow-up | from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) | — |
| Treatment expectancy (Treatment Expectancy Questionnaire) after the first treatment session | after the first treatment session (an expected average of 1 week after admission) | — |
| Satisfaction with the treatment at Posttest | immediately after completion of therapy (an expected average of 3 months after admission) | — |
| Change in Symptom Severity (Obsessive-Compulsive Disorder Scale; OCD-S) measured before every treatment session | from the first treatment session (an expected average of 1 week after admission) to the last treatment session (an expected average of 3 months after admission) on a weekly basis | — |
| Change in Patient-Therapist-Alliance from Pretest to two in-between timepoints to Posttest to Follow-up | from Pretest (admission) to two in-between timepoints (an expected average of 5 and 10 weeks after admission) to Posttest (an expected average of 3 months after admission) to Follow-up (an expected average of 6 months after admission) | Self rating and clinician rating of Helping Alliance Questionaire (HAQ) and Working Alliance Inventory (WAI) |
Countries
Germany
Outcome results
None listed