Intelligence Changes Following Minor Surgery

Intelligence Performance in Adolescence After Early Exposure to Anesthesia and Minor Surgery

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01483313

Enrollment

Registered

2011-12-01

Start date

2011-11-30

Completion date

2012-12-31

Last updated

2014-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypospadia, Inguinal Hernia, Phimosis

Keywords

Anesthestics, Minor surgery, Wechsler Intelligence Scale for Children, Cognitiion

Brief summary

Animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. However results from human studies are conflicted. In present study, the investigators examined the association between early exposure to anesthesia and surgery for minor surgery and intelligence changes in adolescence using the Wechsler Intelligence Scale for Children.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

6 Years to 16 Years

Healthy volunteers

Yes

Inclusion criteria

1. Born from 1995 2. Male 3. Parents or guardian agree to attend this study 4. Undergone minor surgery (Repair of hypospadias, phimosiectomy, cryptorchidectomy or cryptorchidopexy and repair of inguinal hernia) 5. Children who scarify the No.1 to No.3 but no experience of any surgery. 6. Those who undergone minor surgery in Renji Hospital 4-6years ago.

Exclusion criteria

1. Any congenital central nervous system diseases 2. Any congenital heart diseases 3. Any congenital dysgnosia 4. Birth weight less than 2kg 5. Ever been hypoxic encephalopathy when birth

Design outcomes

Primary

Measure	Time frame	Description
Wechsler Intelligence Scale for Children	Average 5 years after surgery	Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.

Secondary

Measure	Time frame	Description
Achenbach Child Behavior Checklist	Average 5 years after surgery	Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.

Countries

China

Outcome results