Postoperative Nausea and Vomiting
Conditions
Brief summary
The purpose of this study is to determine whether continuous infusion of palonosetron after its prophylactic single injection can further reduce the incidence of postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery.
Interventions
DRUGcontinuous infusion of palonosetron added to prophylactic single injection of palonosetron
continuous infusion of palonosetron 0.00075 mg/hour after single injection of palonosetron 0.075mg
DRUGcontinuous infusion of normal saline added to prophylactic single injection of palonosetron
continuous infusion of normal saline after single injection of palonosetron 0.075mg
Sponsors
Incheon St.Mary's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ASA Physical Status 1 or 2 * Elective gynaecological laparoscopic surgery of ≥ 1h duration
Exclusion criteria
* Anti-emetics, steroids, or psychoactive medications within 24 h of study initiation * Vomiting or retching in the 24 h preceding surgery * Cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks before study entry * Ongoing vomiting from gastrointestinal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative nausea and vomiting | 24 hours after surgery |
Secondary
| Measure | Time frame |
|---|---|
| severity of nausea | for 24 hours after sugery |
Countries
South Korea
Contacts
Primary ContactSoo Kyoung Park
Outcome results
None listed