Patients Following Lung Transplantation (Single and Double)
Conditions
Keywords
lung transplantation, whole body vibration, exercise training, pulmonary rehabilitation
Brief summary
Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients following lung transplantation. Exercise training has been shown to be a cornerstone of an inpatient rehabilitation program to reduce muscle dysfunction and improve exercise performance. In our study we will investigate the benefit of a whole body vibration training in addition to a standard pulmonary rehabilitation program that includes endurance and strength training. We will include a total of 140 patients (70 patients \< 1 year after lung Transplantation and 70 patients \> 1 year after lung Transplantation). Our hypothesis is that an addtitional whole body vibration training produces a greater benefit to exercise capacity in lung transplantat patients (LTx).
Interventions
OTHERPulmonary rehabilitation + whole body vibration training
standard inpatient rehabilitation program including endurance and strength plus squats on a vibration plate for 4x2 minutes, 3 times per week
Sponsors
Schön Klinik Berchtesgadener Land
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* participation in an inpatient rehabilitation program * double or single lung transplantation due to chronic obstructive pulmonary disease, Alpha-1-antitrypsine deficiency, interstitial lung disease
Exclusion criteria
* severe exacerbation in the last 4 weeks with the necessity of delivering antibiotics/ corticosteroids * non-compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in 6-minute walking distance | change from baseline to day 21 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in Fmax | change from baseline to day 21 | maximum isometric quadriceps force |
| change in fibre cross sectional area | change from baseline to day 21 | cross sectional area of the M.rectus femoris, measured by ultrasound |
| change in chair rise time | change from baseline to day 21 | chair rise test: to get from a sitting position to a standing, measuring the time for 5 repetitions |
| change in Wmax | change from baseline to day 21 | maximum workload in incremental cycling test |
| change in body cell mass | change from baseline to day 21 | measured by bio-impedance analysis |
| change in IGF-1 | change from baseline to day 21 | IGF-1, measured in a blood sample |
| change in quality of life | change from baseline to day 21 | SF-36 questionnaire and CRQ questionnaire |
Countries
Germany
Outcome results
None listed