Age-related Macular Degeneration
Conditions
Keywords
eggs, Optical Macular Pigment, Age Macular Degeneration, study for the Age Macular Degeneration prevention
Brief summary
This study is to determine the impact of the consumption of eggs rich in lutein/zeaxanthin from lucerne protein concentrate and DHA from microalgae on the plasma levels of these compounds but also on the macular pigment optical density, whose elevation may be beneficial in the prevention of Age-related Macular Degeneration (AMD).
Interventions
OTHERNutritional study
subjects consume 2 eggs per day during 4 months
Sponsors
Roquette Freres
Sanders
Institut Pasteur de Lille
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy subjects (male or female), * 18 to 55 years * Having signed the consent form, * Susceptible to accept the stresses generated by the study, * Insured.
Exclusion criteria
* Corrected Visual Acuity \<8/10th, * History of cardiovascular disease, specifically coronary heart disease, * Characterized dyslipidemia \* Total cholesterol ³ 2.50 g / L, and / or triglycerides ³ 2.00 g / L * Lipid-lowering treatment, * Current smoking or person who stopped smoking less than 6 months * Cataract or cataract surgery, * Diabetes * Body Mass Index (BMI)\> 30 kg/m2, * Taking food supplements in the 3 months preceding the start of the study (carotenoids, omega-3 fatty acids, phytosterols), * Regular consumption in the three months preceding the start of the study products with added phytosterols. * Regular consumption of high fatty fish or shellfish rich in omega-3 (4x a week or more): salmon, sardines, mackerel, herring, trout, tuna, red mullet, sea bass, bream, farmed turbot, mussels, squid / squid, anchovies. * Allergy to eggs * Dieting * Difference significant weight over the last 3 months (\> 3 kg) * Inability to understand or adhere to the protocol * Persons deprived of liberty * People in a position to judicial protection * Pregnant Women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change from baseline in optical density of macular pigment after 4 months of eggs consumption | before the eggs consumption and four months afterwards | optical density of macular pigment was measured with a Heidelberg Retinal Angiograph (HRA)specially modify for the measure of the pigment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change from baseline in lutein and zeaxanthin in plasma and lipoproteins after 4 months of egg consumption | before the eggs consumption and four months afterwards | lutein and zeaxanthin were measured by HPLC |
| change from baseline in fatty acids in plasma and lipoproteins after 4 months of egg consumption | before the eggs consumption and four months afterwards | Fatty acids were measured by Gas Chromatography. |
Countries
France
Outcome results
None listed