Infertility
Conditions
Keywords
antral follicle count, automated antral follicle count, ovarian reserve
Brief summary
The ultrasound unit in Meir Medical Center developed new software to automated ovarian follicle count on the basis of 3D US. The investigators intent to evaluate this software at two steps: * To compared the abilities of the software to physician follicle count. * To evaluate with the software the antral follicle count, as expression to ovarian reserve at 3 different time of the month. The investigators believe that the software measurement of the small follicle can be better than the common antral follicle count that is use today, and by this accurate evaluation of the small follicle the investigators can evaluate the ovarian reserve at any time of the mount, and not only at the early follicular phase that use today.
Detailed description
Antral follicle count (AFC) is one of the methods to evaluate ovarian reserve. But this method is not that straightforward with a lot of inter and intra observe variation. In attempt to overcome this problems we going the verified a new software for automated AFC. At the first step we will compare the human count and the software count of the AFC in 150 exams of ovaries at 3D US. At the second step we will use the software to evaluate ovarian reserve at 50 women before fertility treatment. This woman will be questioned about epidemiologic data (age, ethnicity, medical history) and evaluate at the early follicular phase with blood test for follicle stimulating hormone, luteinizing hormone , E2, anti-mullerian hormone , Prolactin, thyroid-stimulating hormone, Testosterone, Progesterone, 17-hydroxyprogesterone, dehydroepiandrosterone-Sulphate. The evaluation of the AFC by US will be at early follicular phase, late follicular phase and mid luteal phase
Interventions
OTHERultrasound examination for AFC evaluation
Ultrasound examination three times during the menstrual cycle to measure the AFC.
Sponsors
Meir Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* woman under age 40 years all * woman at evaluation before beginning of fertility treatment * woman with regular menstrual cycle
Exclusion criteria
* woman who treat with ovulation induction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antral follicle count accuracy during the menstrual cycle for ovarian reserve evaluation. | Within the 28-35 days of the menstrual cycle. |
Countries
Israel
Contacts
Primary ContactRoni Tepper, professor
Backup ContactMerav Sharvit, doctor
Outcome results
None listed