Risk Factors for Residual Neoplasia After Endoscopic Mucosal Resection

Risk Factors for Local Residual Neoplasia After Convetional Endoscopic Mucosal Resection of Laterally Spreading Tumors

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01478919

Enrollment

127

Registered

2011-11-23

Start date

2010-01-31

Completion date

2011-11-30

Last updated

2013-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

Endoscopic Mucosal Resection, Laterally Spreading Tumor, Local Residual Neoplasia, Colonoscopy, Therapy

Brief summary

Laterally Spreading Tumors (LST) are important precursosrs of invasive colorectal cancer. Endoscopic treatment has replaced surgery in most of the cases. Nevertheless, after conventional Endoscopic Mucosal Resection (CER), Local Residual Neoplasia (LRN) is an issue. Therefore, endoscopic follow-up and treatment are necessary. To decrease its occurrence, the risk factors of LRN shoudl be identified. Thereafter, in high-risk patients, other modalities of initial treatment including Endoscopic Submucosal Dissection (ESD) and surgical treatment, could be considered. The purpose of this prospective study is to identify risk factors associated with the presence of LRN after CER of LSTs.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* all consecutive patients referred for EMR of LST

Exclusion criteria

* polyposis syndromes * previous therapeutic attempt

Design outcomes

Primary

Measure	Time frame	Description
Occurence of Local Residual Neoplasia (LRN)	3 months	LRN was defined as a histologically confirmed neoplastic tissue in the biopsy samples obtained from post-resection scar during follow-up colonoscopy 3 months after endoscopic resection

Secondary

Measure	Time frame	Description
Evaluation of Selected Risk Factors for Local Residual Neoplasia (LRN)	3 months	Evaluation of selected patient- and lesion-related risk factors associated with LRN (gender, age, lesion size, location, morphology, pit pattern, histology, type of resection, and others)

Countries

Czechia

Outcome results