Celiac Disease
Conditions
Keywords
celiac disease, gluten-free diet, gluten peptides, feces
Brief summary
The purpose of this study is to monitor of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces.
Detailed description
Certain immunotoxic peptides from gluten are resistant to gastrointestinal digestion and can interact with celiac patient factors to trigger immunological response. Gluten-free diet (GFD) is the only effective treatment for celiac disease (CD) and its compliance should be monitored to avoid accumulative damage. However, practical methods to monitor diet compliance and to detect the origin of an outbreak of celiac clinical symptoms are not available. This study assesses the capacity to determine the gluten ingestion, and to monitor the GFD compliance in celiac patients by detection of gluten and gliadin 33-mer equivalent peptidic epitopes in human feces.
Interventions
OTHERDetection of gluten in feces
Detection of Gluten in Feces
Sponsors
Instituto Hispalense de Pediatría, Seville, Spain
University of Seville
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* Celiac patient * 1-12 years old * Written informed consent
Exclusion criteria
* Known inflammatory bowel diseases * Participation in any other studies involving investigational concomitantly or within two weeks prior to entry into the study and during the course of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Monitoring of gluten-free diet compliance in celiac patients | April-July 2011 (3 months) | Usual gluten diet for celiac (home diet not modified for this trial) |
Countries
Spain
Outcome results
None listed