Hypercholesterolemia
Conditions
Brief summary
The aim of this clinical study was to determine the efficacy on plasma cholesterol-lowering of a water dispersible formulation of plant sterol (WD-PS) preparation versus plant sterol esters (PS-ester), consumed within dairy products.
Detailed description
Forty-seven hyperlipidemic subjects (25 males and 22 females, age 19-75 years at baseline) completed the double-blind, randomized, crossover study.
Interventions
DIETARY_SUPPLEMENTWD-PS intervention phase
2g/d of free plant sterol in 100g yogurt
DIETARY_SUPPLEMENTPS-Ester intervention phase
2g/d of free plant sterol in 100g yogurt
DIETARY_SUPPLEMENTplacebo
100g/d yogurt with no added plant sterol
Sponsors
University of Manitoba
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
19 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy individuals aged 19-60 yr * plasma LDL-C levels \> 3.0mmol/l * TG \< 4.5mmol/l * body mass index (BMI) between 20 and 30 kg/m2.
Exclusion criteria
* history of recent or chronic use of oral hypolipidemic therapy, including fish oils, or probucol within the last 3 months * history of chronic use of alcohol (\>2 drinks/d) * smoking * myocardial infarction, coronary artery bypass, sitosterolaemia, kidney disease, liver disease or other major surgical procedures within the last six months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid Profile | Change from Baseline in lipid profile at 4 weeks (end of the phase) |
Countries
Canada
Outcome results
None listed