Comparison of TIVA (Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing Postoperative Nausea and Vomiting

Comparative Study of TIVA(Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing PONV(Postoperative Nausea and Vomiting)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01478165

Enrollment

100

Registered

2011-11-23

Start date

2011-09-30

Completion date

2011-11-30

Last updated

2011-11-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea and Vomiting

Keywords

Palonosetron, PONV(postoperative nausea and vomiting), TIVA(Total intravenous anesthesia)

Brief summary

A total intravenous anesthesia (TIVA) is a useful anesthetic technique that reduces the incidence of postoperative nausea and vomiting (PONV). Investigator hypothesized the incidence of PONV can be further reduced when palonosetron is added to TIVA.

Interventions

DRUGTotal intravenous anesthesia

Total intravenous anesthesia plus normal saline 1.5 ml immediately before induction of anesthesia

DRUGTotal intravenous anesthesia plus palonosetron

Total intravenous anesthesia plus palonosetron 0.075 mg(1.5 ml)immediately before induction of anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* ASA Physical Status 1 or 2 * Elective gynaecological laparoscopic surgery of ≥ 1h duration

Exclusion criteria

* Anti-emetics, steroids, or psychoactive medications within 24 h of study initiation * Vomiting or retching in the 24 h preceding surgery * Cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks before study entry * Ongoing vomiting from gastrointestinal disease

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative nausea and vomiting	For 24 hours after surgery

Secondary

Measure	Time frame
Severity of nausea	For 24 hours after surgery

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026