Ischemic Reperfusion Injury, Rheumatic Disease of Heart Valve
Conditions
Keywords
Ischemia reperfusion injury, Cardiopulmonary bypass, Remote Ischemic Postconditioning, Other Functional Disturbances Following Cardiac Surgery
Brief summary
The purpose of this study is to determine whether Remote Ischemic Perconditioning is effective on Acute kidney injury in adult valve replacement.
Detailed description
Methods: Patients meeting the requirement will be randomized into 2 groups: the treatment group consisted of three 5-minute cycles left lower limb ischemia, induced by inflating a blood pressure cuff on the lower limb to 600 mmHg with an intervening 5 minutes of reperfusion, during which time the cuff was deflate; the control group consisted of placing an uninflated cuff on the left lower limb for 30 minutes. The postconditioning protocol was applied after the aortic cross-clamping. The clinical data of inotropes requirement, drainage, ventilation and intensive care time will be recorded. Venous blood samples will be taken perioperatively for detecting concentration of troponin I (cTnI), Myocardial enzyme, Renal function, Cystatin c, and High-sensitivity c-reactive protein(HS-CRP).
Interventions
the treatment group consisted of three 4-minute cycles left lower limb ischemia,induced by inflating a blood pressure cuff on the lower limb to 600 mmHg with an intervening 4 minutes of reperfusion ,during which time the cuff was deflate;the control group consisted of placing an uninflated cuff on the left lower limb for 24 minutes.The postconditioning protocol was applied after the aortic cross-clamping.
Sponsors
Central South University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* rheumatic heart valve disease requiring selective aortic or double valve(aortic and mitral valve) replacement
Exclusion criteria
* infective endocarditis congenital valve disease previous cardiac surgery complicated with rereplace valve * Renal dysfunction * diabetes * coronary artery disease * hypertension * peripheral vascular disease affecting the lower limb free of arteriovenous fistula * receiving aspirin, corticosteroids, angiotensin-converting enzyme inhibitors or statin perioperatively
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal function | within the first 48h after cardiac surgery |
Secondary
| Measure | Time frame |
|---|---|
| concentration of troponin I (cTnI) | within 48h after cardiac surgery |
| Myocardial enzyme | within 48h after cardiac surgery |
| Cystatin C | within 48h after cardiac surgery |
| High-sensitivity c-reactive protein(HS-CRP) | within 48h after cardiac surgery |
Countries
China
Contacts
Primary ContactLuo Wanjun, M.D.
Backup ContactLv Hongwei, M.D.
Outcome results
None listed