Cerebral Blood Circulation in Patients With Posterior Fossa Brain Tumor

Cerebral Autoregulation and Carbon Dioxide Reactivity in Patients With Posterior Fossa Tumor

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01476670

Enrollment

Registered

2011-11-22

Start date

2012-07-31

Completion date

Unknown

Last updated

2011-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Tumor

Keywords

Posterior fossa brain tumor, Cerebral blood flow, Cerebral autoregulation, Carbon dioxide reactivity, Transcranial Doppler

Brief summary

The normal cerebral blood flow is guided by factors such as cerebral autoregulation (CA) and carbon dioxide reactivity (CO2R). Authors have demonstrated that CA and CO2R may be impaired in presence of intracranial tumors.Most studies pertaining to assessment of CA and CO2R in patients with brain tumors is limited to supratentorial tumors. Due to their anatomic location, posterior fossa tumors result in obstruction of ventricular outflow, produce hydrocephalus and features of raise intracranial pressure (ICP). It is possible that lesions in the posterior fossa may affect CA and CO2R. It should also be noted that posterior fossa surgeries are carried out in positions such as prone, lateral and sitting. Altered surgical positions themselves affect systemic hemodynamics which may influence cerebral blood flow; with presence of anesthetics further compromising the blood flow to the brain. Understanding the homeostatic mechanisms of CA and CO2R may help in deciding proper positioning of patients and maintenance of intraoperative hemodynamic. The aim of this observational study was to evaluate CA and CO2R in patients with posterior fossa tumor prior to surgical decompression of the lesion.

Interventions

OTHERMonitoring

Transcranial Doppler will be used to assess the cerebral autoregulation and carbon dioxide reactivity of patients with posterior fossa tumor

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* All patients with posterior fossa tumor * Scheduled for elective surgery * History of recent ventriculoperitoneal shunt (within 24 hours)

Exclusion criteria

* previous craniotomy * patients on ventilatory support * history of cerebrovascular accident * syncope or carotid artery disease * anemia * polycythemia * patients on vasoactive medications * those suffering from medical conditions such as diabetes mellitus and hypertension.

Countries

India

Contacts

Primary ContactHemanshu Prabhakat, MD

prabhakaraiims@yahoo.co.in9868398205

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026