Pneumonia, Pulmonary Atelectasis, Respiratory Insufficiency
Conditions
Keywords
Postoperative pulmonary complications, Laparoscopic surgery
Brief summary
The purpose of this study is to describe the magnitude of respiratory complications after laparoscopic hysterectomy and cholecystectomy.
Detailed description
The purpose of this study is to describe change in pulmonary function and incidence of respiratory complications after laparoscopic surgery. The investigators will include 60 women scheduled for laparoscopic hysterectomy or cholecystectomy. The investigators will measure the pulmonary function by different methods during and for 2 hours after surgery. Moreover, the incidence of respiratory complications including pneumonia, respiratory failure and radiologically verified atelectasis will be registered.
Interventions
None listed
Sponsors
Herlev Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Women * \> 45 years old * Scheduled for laparoscopic cholecystectomy or laparoscopic hysterectomy
Exclusion criteria
* Weight \< 50 kg * Pregnant or nursing * Cardiac failure * Renal failure * Inability to breath through a facial mask * Inability to give informed consent * Inability to keep arterial oxygen saturation above 90% without supplemental oxygen
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial oxygen tension 2 hours after surgery | 2 hours after end of surgery | Change in arterial oxygen tension 2 hours after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Connection between pulmonary shunt and need for oxygen supplement | 2 hours postoperatively and at discharge from the postanesthesia care unit | The connection between pulmonary shunt 2 hours after surgery and need for oxygen supplement at discharge from the postanesthesia department in order to keep peripheral oxygen saturation above 93%. |
| Oxygenation index 2 hours after surgery | 2 hours after end of surgery | Change in oxygenation index (PaO2/FiO2) 2 hours after surgery |
| FEV1 and FVC 2 hours after surgery | 2 hours after end of surgery | Change in FEV1 and FVC 2 hours after surgery |
| Pulmonary shunt 2 hours after surgery | 2 hours after end of surgery | Change in pulmonary shunt 2 hours after surgery |
| Ventilation-perfusion ratio 2 hours after surgery | 2 hours after end of surgery | Change in ventilation-perfusion ratio from baseline to 2 hours after surgery |
| Arterial oxygen saturation 2 hours after surgery | 2 hours after surgery | Change in arterial oxygen saturation 2 hours after surgery |
| Respiratory frequency 2 hours after surgery | 2 hours after surgery | Change in respiratory frequency 2 hours after surgery |
| Oxygen supplement at discharge from the postanesthesia care unit | At discharge from the postanesthesia care unit, which will be approximately 2 hours after surgery | The proportion of patients who received oxygen supplement at discharge from the postanesthesia care unit in order keep arterial oxygen saturation above 93% |
| Pulmonary shunt 24 hours after surgery | 24 hours after surgery | Change in pulmonary shunt 24 hours after surgery |
| Ventilation-perfusion ratio 24 hours after surgery | 24 hours after surgery | Change in ventilation-perfusion ratio 24 hours after surgery |
| Arterial oxygen saturation 24 hours after surgery | 24 hours after surgery | Change in arterial oxygen saturation 24 hours after surgery |
| Respiratory frequency 24 hours after surgery | 24 hours after surgery | Change in respiratory frequency 24 hours after surgery |
| Length of stay | Participants will be followed for the duration of hospital stay, an expected average of 3 days | Length of stay at the hospital |
| Pneumonia | Participants will be followed for the duration of hospital stay, an expected average of 3 days | Incidence of pneumonia from surgery to discharge from hospital |
| Respiratory failure after surgery | Participants will be followed for the duration of hospital stay, an expected average of 3 days | Incidence of respiratory failure from surgery to discharge from hospital |
| Atelectasis | Participants will be followed for the duration of hospital stay, an expected average of 3 days | Incidence of radiologically verified atelectasis from surgery to discharge from hospital |
| High temperature | Participants will be followed for the duration of hospital stay, an expected average of 3 days | Incidence of a high temperature ( above 38 degrees celsius) from surgery to discharge from hospital |
| FEV1 and FVC 24 hours after surgery | 24 hours after surgery | Change in FEV1 and FVC 24 hours after surgery |
Countries
Denmark
Outcome results
None listed