Inflammation, Oxidative Stress
Conditions
Keywords
Oxidative stress, inflammation, blood flow
Brief summary
The investigators investigate the impact of an encapsulated fruit, berry and vegetable juice powder concentrate on oxidative stress, inflammation and blood flow before and post exercise in overweight, middle-aged, women. Main hypotheses (H1): * The nutraceutical has an impact on oxidative stress reduction. * The nutraceutical has an impact on inflammation. * The nutraceutical has an impact on blood flow and microcirculation. * Walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers. * Walking exercise for 30 minutes has an impact on blood flow and microcirculation * The combination of nutraceutical supplementation + walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers, and on blood flow/microcirculation.
Interventions
DIETARY_SUPPLEMENTnutraceutical group
6 capsules of supplement or placebo for 8wk
Sponsors
Green Beat
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* women * BMI \> 27 * praemenopausal * non smokers * eligibility for exercise * 4wk wash out
Exclusion criteria
* male * all people not matching this age group * BMI \> 40 and \< 27 * peri- or postmenopausal women * smokers * all women taking dietary supplements * all women that fail in ergometric exercise eligibility testing, refering to the standards in sports medicine (e.g.: significant ST-decrease or increase, blood pressure \> 240 mmHg, tachycardia, polymorphic extrasystolia, cyanosis, bradyarrhythmia..) * Diabetics * osteoporosis or osteopenia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Carbonyl groups on protein, oxidized LDL, Malondialdehyde, TNF-alpha, IL-6, Trombelastometry and peripheral microcirculation | 6 months | Carbonyl groups on protein as indicators of protein oxidation; oxidized LDL, Malondialdehyde as indicators of Lipidoxidation; TNF-alpha, IL-6 as indicators of inflammation; Trombelastometry: clotting time, thrombocyte ahesion, trombocyte aggregation from whole blood as indicators for blood flow and hemostasis; Peripheral microcirculation in subcutis as indicator for blood flow in peripheral subcutis. |
Countries
Austria
Outcome results
None listed