Lyme Borreliosis
Conditions
Keywords
Lyme borreliosis, Erythema migrans, Doxycycline, Subjective symptoms, Outcome
Brief summary
The investigators will compare the outcome of three groups of erythema migrans patients treated with doxycycline: a group without any accompanying symptoms, with mild symptoms and with severe symptoms that require lumbar puncture.
Detailed description
Patients with erythema migrans treated with doxycycline for two weeks will be followed-up for one year (at 2 weeks, 2, 6 and 12 months) clinically and also by filling in the questionnaire to assess the presence of certain symptoms. Also the control group of their friends or relatives without a history of Lyme borreliosis will be included. The presence of their (unspecific) symptoms will also be recorded by the questionnaire at the time of enrollment and at 6 and 12 months.
Interventions
DRUGDoxycycline
100 mg PO bid, 14 days
Sponsors
University Medical Centre Ljubljana
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* presence of erythema migrans * \>15 years old * informed consent
Exclusion criteria
* pregnancy * lactation * multiple erythema migrans * already treated with antibiotic for this episode of Lyme borreliosis * allergy to doxycycline * treatment with drugs with known interactions with doxycycline * cerebrospinal fluid pleocytosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing of objective sequelae and post-treatment subjective symptoms in three groups of erythema migrans patients treated with doxycycline: with no accompanying symptoms, with mild and with severe symptoms at the beginning. | 1 year follow-up |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of subjective symptoms between erythema migrans patients treated with doxycycline and control subjects without a history of Lyme borreliosis. | 1 year follow-up |
Countries
Slovenia
Outcome results
None listed