Thoraco-abdominal Volume Variations During Anesthesia Studied by OEP.

Thoraco-abdominal Volume Variation During Recovery From Total Intravenous Anesthesia Studied by Opto-electronic Plethysmography (OEP).

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01474850

Enrollment

Registered

2011-11-18

Start date

2011-11-30

Completion date

2012-11-30

Last updated

2014-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical Ventilation

Keywords

mechanical ventilation, pressure control ventilation, lung recruitment, positive end expiratory pressure, opto-electronic plethysmography, chest wall volume variation, intravenous anesthesia

Brief summary

The aim of this study is to examine chest wall volume changes monitored by opto-electronic plethysmography during recovery from anesthesia and early postoperative period.

Detailed description

This is prospective, randomized clinical trial in subjects undergoing elective surgery requiring general anesthesia. Opto-electronic plethysmography (OEP) has been developed as a non-invasive method for the analysis of chest wall motion, allowing highly accurate measurements of chest wall volume changes of different respiratory compartments in various conditions. The investigators set out to use this technology to study chest wall volume changes during recovery from total intravenous anesthesia (from discontinuing the anesthetic agent till extubation) and early postoperative period. The study protocol compares two different approaches: 1. The group receiving recruitment maneuver (RM) immediately after intubation and positive end expiratory pressure (PEEP) 7 cm H20 until extubation. Inspiratory oxygen concentration 40% during recovery from anesthesia. 2. The group not receiving RM, PEEP 0 cm H2O and inspiratory oxygen concentration 100% during recovery from anesthesia. The volume changes of the chest wall is monitored continuously by OEP, functional residual capacity (FRC) and arterial oxygenation are measured at the defined points in the protocol.

Interventions

PROCEDURElung recruitment maneuver

RM: peak inspiratory pressure 30 cmH2O, PEEP 15 cm H20 FiO2 0,4 (from end of surgery till extubation)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* age \> 18 years * ASA classification I-II, scheduled for elective surgery requiring general anesthesia * signed informed consent

Exclusion criteria

* BMI \> 35 * co-existing respiratory disease (COPD, asthma ) * patient refusal * pregnancy * deformities of the thorax

Design outcomes

Primary

Measure	Time frame	Description
Opto-electronic plethysmography (OEP)	1. 5 min after each of these steps: the onset of the mechanical ventilation, the randomization, the end of the surgery 2. continuously during recovery 3. one hour after extubation	Respiratory movements and thoracic and abdominal volume changes is recorded continuously using OEP (OEP system, BTS,Milan, Italy) by analysing the movements of retro-reflective markers using six video cameras connected to an automatic optoelectronic motion analyser.

Secondary

Measure	Time frame	Description
Functional residual capacity (FRC)	5 min after each of these steps: the onset of mechanical ventilation, the randomization, the end of the sergery	—
Oxygenation (paO2)	5 min after each of these steps: the onset of mechanical ventilation, the randomization, the end of the surgery, extubation	Arterial blood gas measurement.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026