Endotoxemia, Inflammation, Oxidative Stress
Conditions
Keywords
oxidative stress, inflammation, endotoxemia, strenuous exercise
Brief summary
We investigate the impact of a probiotic-based dietary supplement on oxidative stress and endotoxemia before and after strenuous exercise. Hypotheses (H1): * Supplementation has an influence on oxidative stress parameters before and post exercise * Supplementation has an influence on parameters of endotoxemia and inflammation before and post exercise * Strenuous exercise has an influence on parameters of oxidative stress, inflammation and endotoxemia
Interventions
DIETARY_SUPPLEMENTprobiotic-based dietary supplement
24 trained men receive a probiotic-based dietary supplement for 16 weeks. Dosage 3x 10-9 per day
DIETARY_SUPPLEMENTplacebo
24 trained men receive a placebo for 16 weeks with same dosage compared to active group
Sponsors
Green Beat
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
30 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* trained men * 30 - 45 years * non-smokers * 4wk wash out of all dietary supplements
Exclusion criteria
* untrained people (VO2max \< 55 ml x kg-1) * female * all people not matching this age group * smokers * all men taking dietary supplements * all men that fail in ergometric exercise eligibility testing, refering to the standards in sports medicine (e.g.: significant ST-decrease or increase, blood pressure \> 240 mmHg, tachycardia, polymorphic extrasystolia, cyanosis, bradyarrhythmia..) * all people that are not adjudged as Healthy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| markers of oxidative stress, endotoxemia and inflammation | 6 months |
Countries
Austria
Outcome results
None listed