Metabolic Availability of Lysine From Rice

Application of the Indicator Amino Acid Oxidation Technique for the Determination of Metabolic Availability of Lysine From Cooked Rice Protein in Adult Men

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01474226

Enrollment

Registered

2011-11-18

Start date

2011-01-31

Completion date

2011-11-30

Last updated

2013-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Adults

Keywords

lysine, rice, bioavailability

Brief summary

The purpose of this study is to investigate the digestibility of the amino acid lysine in cooked rice in adult men using stable isotope technique.

Detailed description

The investigators objective is to determine the metabolic availability (MA) of lysine in cooked white rice protein using the indicator amino acid oxidation (IAAO) technique. Five men will receive graded levels (20, 40, and 60, and 70%) of the lysine requirement of 35 mg/kg/d as a crystalline AA mixture,and cooked rice protein (20, 40 and 60%), respectively.

Interventions

DIETARY_SUPPLEMENTAmino Acid Crystalline Lysine Amino Acid Mix

crystalline lysine from AA MIX (20, 40, and 60% of the mean lysine requirement of 35 mg/kg/d) Lysine will be given in the form of L-Lysine-HCl, Sigma-Aldrich Brand.

DIETARY_SUPPLEMENTCooked Rice containing Lysine

Lysine (20,40 and 60 % of the mean lysine requirement) from Cooked Rice

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy Adult males (18 to 50years old)

Exclusion criteria

* A history of recent weight loss or illness * Use of any medication at the time of entry into the study.

Design outcomes

Primary

Measure	Time frame	Description
Metabolic Availability of lysine	Baseline	3 breath samples will be taken to provide a baseline F13CO2 measurement (Level of phenylalanine oxidation). Breath samples will be collected and analyzed for 13CO2 enrichment.

Secondary

Measure	Time frame	Description
Metabolic Availability of Lysine	Post Tracer Infusion (between 150 and 240 min of tracer infusion)	4 breath samples will be taken to provide F13CO2 measurement (Level of phenylalanine oxidation).Breath samples will be collected and analyzed for 13CO2 enrichment.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026