Dental Caries
Conditions
Keywords
dental caries/prevention and control, oral health, cariostatic agents
Brief summary
Aim: to determine the optimal Ca2+ concentration with 905 ppm F as NaF. Study design: Experimental study in 10 volunteers. Single blind mouth rinse with calcium lactate solution (150; 75; 0 mM Ca-lactate) is immediately followed by a standard fluoride rinse. Procedure: Rinses are performed in the evening. The rinse combinations are given in a random order, and the subjects are unaware of the sequence. At least 3 days separates the use of each rinse. Dosage: 20 mL and 1 minute rinse with each solution. Saliva samples: Twelve hours after rinsing, unstimulated saliva samples are collected by expectoration. Analysis: The fluoride concentration in saliva samples are analysed Statistics and data handling: Fluoride in saliva 12 hours after rinsing are examined by one-way ANOVA, repeated measures design.
Interventions
DRUGcalcium lactate solution
Calcium lactate solution 75 mM, 150 mM, 175 mM and placebo
Sponsors
Karolinska Institutet
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years or older * 10 natural teeth or more * willing to refrain from use of fluoride containing products * signed informed consent
Exclusion criteria
* less than 10 natural teeth * reduced cognitive skills * does not speak and/or understand Swedish * ongoing oral or systemic infections * pregnancy * breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fluoride concentration in resting saliva | 12 hours after rinse |
Secondary
| Measure | Time frame |
|---|---|
| Discomfort by calcium lactate rinse | 12 hours after rinse |
Countries
Sweden
Outcome results
None listed