Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients

Effect of a Closed Loop Ventilation Strategy on Reducing the Total Duration of Mechanical Ventilation of Intubated Intensive Care Unit Patients: A Randomized Controlled Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01472302

Enrollment

229

Registered

2011-11-16

Start date

2012-04-30

Completion date

2014-01-31

Last updated

2014-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure, All Intubated Patients

Brief summary

Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both like PCV and PSV automatically. Some studies suggest that ASV can reduce the weaning time in ICU patients. The investigators hypothesized that using ASV from the beginning of intubation can reduce the total duration of MV and LOS in the ICU when compared to conventional modes such as PCV+PSV

Interventions

DEVICEPressure Controlled Ventilation

Ventilation protocol (6-8 ml/kg tidal volume) according to our ICU

DEVICEAdaptive Support Ventilation

Ventilation protocol according to the patients ideal body weight

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Intubated and mechanically ventilated ICU patients for more than 24 hours

Exclusion criteria

* Patient with a tracheostomy * Patients under home mechanical ventilation

Design outcomes

Primary

Measure	Time frame
Duration of mechanical ventilation	1 year

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026