Metabolic Syndrome, Type 2 Diabetes
Conditions
Keywords
Glycemic Index, LoBAG Diet, Insulin, Glucagon
Brief summary
The purpose of this study is to determine the effect of various foods and/or food substances such as fats or proteins on the blood glucose and insulin concentrations in people with and without type 2 diabetes.
Detailed description
Various foods or food substances are given as a test meal. The metabolic response is determined at various times after the administration of the meal (e.g. blood glucose, and other hormones and metabolites).
Interventions
OTHERwater, glucose with or without amino acid
240 ml water, 50 g glucose ± 1 mmol amino acid/kg lean body mass
Sponsors
Minneapolis Veterans Affairs Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects with or without type 2 diabetes * C-Peptide \> 1.5 ng/ml * Able to come to the Minneapolis VA Medical Center on several occasions over 2-4 weeks
Exclusion criteria
* Body mass index \> 40 * hematologic abnormalities * liver disease * kidney disease * congestive heart failure * life threatening malignancies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood glucose concentration | several time points after ingestion of test substance | Test substances will be given at 0800 hr and blood drawn at several time points up to 5 hours after the meal. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum insulin concentration | Several time points after ingestion of test substance | Test substances will be given at 0800 hr and blood drawn at several time points up to 5 hours after the meal. |
Countries
United States
Outcome results
None listed