Thyroid Cancer Patients
Conditions
Keywords
well differentiated thyroid cancer, Carum Carvi, Normal controls
Brief summary
Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite being on suppressive dose of levothyroxin. TSH level returned to normal after discontinuation of the Carum carvi. This observation led to a pilot study for evaluation of the effect of carum carvi on thyroid function.
Interventions
DRUGCarum Cravi
40mg/kg of body weight
DRUGPlacebo
Placebo
Sponsors
Pharmaceutical Research Center
Mashhad University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-65 * Hypothyroid patients under treatment with levothyroxin * Normal euthyroid patients with no goiter
Exclusion criteria
* Pregnancy or lactation * Severe lung or gasterointestinal disease * Heart failure or renal failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Thyroid and thyrotropin values from baseline at 2 and 6 weeks | 0-2-6 Weeks | TSH, Free T4, Free T3, T4RIA and T3RIA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of hypothyroidism index from baseline at 2 and 6 weeks | 0,2 and 6 weeks | Hypothyroidism Index |
Countries
Iran
Contacts
Primary ContactSeyed Rasoul Zakavi, MD,IBNM
Backup ContactZohre Mousavi, MD, IBE
Outcome results
None listed