Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01470586

Enrollment

Registered

2011-11-11

Start date

2009-05-31

Completion date

2011-06-30

Last updated

2011-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Rectal Resection, Colorectal Cancer, Oxidative Stress

Keywords

Colorectal cancer, Surgical resection, Oxidative Stress Markers, Controls

Brief summary

Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal cancer undergo surgical treatment (preoperatively during the intervention and postoperatively) and controls.

Detailed description

Study of the impact of surgery on Lipid peroxidation, Protein peroxidation, damage by nitrogens, and RNA peroxidation, in patients undergo surgical resection for colorectal cancer and compared with controls, and validation of the responsiveness of oxidative stress markers on surgery

Interventions

PROCEDURESurgery for colorectal cancer

Surgical resection of colorectal cancer

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

25 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with colorectal cancer * Controls

Exclusion criteria

* ASA\>3 * Metastatic Disease * Acute bowel obstruction * Acute bowel perforation * BMI\<30 * Chronic Systemic or Autoimmune Diseases * Smokers * Alcohol consumers

Design outcomes

Primary

Measure	Time frame	Description
Comparison of Oxidative stress markers in patients with colorectal cancer and controls	up to 2 years	Oxidative stress markers variation (8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG) during and after surgery for colorectal cancer, and compare with controls

Secondary

Measure	Time frame	Description
Validation of oxidative stress markers in patients with colorectal cancer undergo surgical resection	up to 2 years	Validation of the responsiveness of markers of oxidative stress 8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG)on surgery

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026