Total Knee Arthroplasty
Conditions
Keywords
Adductor-Canal-Blockade, Femoral Nerve Block, Postoperative Pain, Total Knee Arthroplasty
Brief summary
The aim of this study is to investigate the efficacy of the Adductor-Canal-Blockade versus the Femoral Nerve Block on muscle strength, pain and mobilization after total knee arthroplasty. We hypothesize that the Adductor-Canal-Blockade has the same effect on pain and morphine consumption as the Femoral Nerve Block, but without the same reduction in quadriceps muscle strength.
Interventions
PROCEDUREAdductor-Canal-Blockade
US-guided Adductor-Canal-Blockade with Ropivacaine
PROCEDUREFemoral Nerve Block
US-guided Femoral Nerve Block with Ropivacaine
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* ASA 1-3 * BMI \> 18 og \< 40 * total knee arthroplasty in spinal anesthesia
Exclusion criteria
* Can not cooperate to the exam * Do not speak or understand Danish * Drug allergy * Alcohol or drug abuse * Daily consumption of strong opioids * Rheumatoid arthritis * Intake of glucocorticoids * Effect of spinal anesthesia stopped prior to performing the regional block
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in quadriceps muscle strength between the Adductor-Canal-Blockade and the femoral nerve block | 24 h postoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sedation | 2-24 hours | — |
| The difference in adductor muscle strength between the Adductor-Canal-Blockade and the Femoral Nerve Block | 24 h postoperatively | — |
| Pain during flexion of the knee | 2-24 hours | 0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively. |
| Zofran consumption | 0-24 hours | Number of patients recieveing zofran postoperatively |
| The difference in mobilization between the groups | 24 hours | — |
| Total morphine consumption | 0-24 hours | — |
| Postoperative nausea | 2-24 hours | — |
| Postoperative vomiting | 0-24 hours | — |
| Pain at rest | 2-24 hours | 0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively. |
Countries
Denmark
Outcome results
None listed