Breast Cancer, Colon Cancer, Hypodontia, Ovarian Cancer
Conditions
Keywords
screening, genetic, cancer
Brief summary
The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia). Should this prove to be the case, these women could be offered regular clinical controls and prophylactic removal of their ovaries when menopause enters and the ovaries are no longer functional (producing hormones). If there is a connection between congenital hypodontia and the development of different types of cancer, the investigators will perform a genetic screening in families with increased risk of cancer and hypodontia for changes in relevant genes, based on the current literature. The investigators hereby search for new genes, which in a changed form leads to an increased risk of cancer and thereby enables us to perform genetic screening in risk families.
Interventions
None listed
Sponsors
Danish Cancer Society
Arvid-Nilsson Foundation
University of Aarhus
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* confirmed suspicion of ovarian cancer.
Exclusion criteria
* suspicion of ovarian cancer disproved.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence rates of hypodontia in women with ovarian cancer | one year |
Secondary
| Measure | Time frame |
|---|---|
| Genetic causes for hypodontia and ovarian cancer | two years |
| Prevalence rates of hypodontia in patients with a known risk for epithelial cancer | one year |
Countries
Denmark
Contacts
Primary ContactMaria Cathrine C. V. Schmidt, MD, PhD-student
Backup ContactJan Blaakaer, Professor
Outcome results
None listed