Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01470014

Enrollment

Registered

2011-11-10

Start date

2011-10-31

Completion date

2014-12-31

Last updated

2015-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Isolated Noncompaction of the Ventricular Myocardium, Left Ventricular Noncompaction

Keywords

isolated left ventricular non-compaction, cardiac computed tomography, cardiac magnet resonance imaging, echocardiography

Brief summary

The diagnostic criteria for isolated left ventricular non-compaction cardiomyopathy (IVNC) have been well established for echocardiography and cardiac magnetic resonance, such validation is lacking for computed tomography (CT). Such criteria are of great clinical relevance as a growing number of patients undergo a cardiac CT scan in daily clinical routine. The investigators aim to test the diagnostic accuracy of cardiac CT in distinguishing IVNC from lesser degrees of trabecular layering seen in potential differential diagnoses such as cardiomyopathies and left ventricular hypertrophy or dilation. The investigators hypothesize that echocardiographic diagnosed pathological trabeculation can be distinguished by determining the ratio of non-compacted to compacted myocardium on cardiac CT.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Established diagnosis of IVNC or differential diagnosis * Age: Men \> 30 years, women \> 50 years without menstruation for at least 2 month. * Written informed consent to participate

Exclusion criteria

Contraindication for cardiac CT * Renal insufficiency (GFR \< 60ml/min) * Known allergy to iodinated contrast agent * Known Hyperthyroidism * Non-sinus rhythm * Known premature ventricular or supraventricular beats * Hypotension (systolic blood pressure \< 100mmHg) Contraindication for CMR * Implanted cardiac pacemaker or defibrillator * Other implanted medical devices (e.g. implantable cardioverter-defibrillator) * Claustrophobia * Known premature ventricular or supraventricular beats * Pregnancy * Claustrophobia

Countries

Switzerland

Outcome results