A Study of Onset of Action of Loratadine and Fexofenadine in Participants With Seasonal Allergic Rhinitis (P08712)

A Double-Blind, Parallel, Randomized, Placebo Controlled Trial to Evaluate Onset of Action of Loratadine and Fexofenadine in Subjects With Seasonal Allergic Rhinitis in a Pollen Challenge Chamber

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01469234

Enrollment

255

Registered

2011-11-10

Start date

2011-10-31

Completion date

2011-11-30

Last updated

2015-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinitis

Brief summary

The purpose of this study is to determine the onset of action of two commercially available over-the-counter antihistamines (Loratadine and Fexofenadine) in a model of seasonal allergic rhinitis (SAR). Participants undergo sensitization exposures to Mountain Cedar (juniperus ashei) pollen in a Biogenics Research Chamber; those who demonstrate an adequate allergic response determined by the Major Symptom Complex (MSC) score will then receive drug.

Interventions

DRUGloratadine

loratadine, one 10 mg tablet, orally

DRUGfexofenadine

fexofenadine, one 180 mg tablet, orally

DRUGplacebo to loratadine

one tablet, orally

DRUGplacebo to fexofenadine

one tablet, orally

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Female participants of child bearing potential must demonstrate a negative urine pregnancy test at Screening (Visit 1) and Visit 4 (prior to randomization) and agree to use (and/or have their partner use) 2 acceptable methods of birth control beginning at the Screening visit and throughout the study. * Willing to stop use of current decongestant and allergy medications at the start of the washout period (Visit 1) and during the trial. * Documented history or participant-reported history of seasonal allergic rhinitis caused by mountain cedar pollen within the last 2 years and documented or participant-reported symptoms over at least the last 2 mountain cedar allergy seasons. * Documented skin testing (prick with wheal ≥ 4 mm larger than the diluent) within the last 1 year to mountain cedar pollen present. * Capable of reading English. * Body mass index (BMI) \<35.

Exclusion criteria

* Any significant medical condition which, in the judgment of the investigator, is a contraindication to the use of loratadine, fexofenadine or might interfere with the trial. These may include thyroid disease (e.g., hyperthyroidism, hypothyroidism), uncontrolled diabetes mellitus, coronary heart disease, ischemic heart disease, elevated intraocular pressure, prostatic hypertrophy. * Have started allergen immunotherapy within 1 month preceding enrollment or participants starting allergen immunotherapy or anticipating immunotherapy dose change during the trial. Xolair (omalizumab) may not be used within 4 years prior to trial participation. * Known allergy or intolerance to loratadine, desloratadine, or fexofenadine. * History of rhinitis medicamentosa. * Use of systemic (oral, rectal, injectable), topical (up to 1% topical hydrocortisone is permitted), or nasal corticosteroids in the last 30 days or current or expected use of disallowed medications as listed in the protocol. * Asthma, with the exception of mild intermittent asthma.

Design outcomes

Primary

Measure	Time frame	Description
Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	From time of sensitization (time 0) to end of visit (~8 hours)	The MSC Score is calculated as the sum of 5 individual symptom scores for Runny Nose, Itchy Nose, Sneezing, Watery Eyes, and Itchy Eyes. Each individual symptom is rated on a 5-point scale of severity: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The total MSC score ranges from 0 - 25. Increasing scores are associated with increasing severity.

Secondary

Measure	Time frame	Description
Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	From time of sensitization (time 0) to end of visit (~8 hours)	The individual symptom score for Itchy Nose was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Itchy Nose symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.
Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	From time of sensitization (time 0) to end of visit (~8 hours)	The individual symptom score for Sneezing was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Sneezing symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.
Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	From time of sensitization (time 0) to end of visit (~8 hours)	The individual symptom score for Water Eyes was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Watery Eyes symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.
Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	From time of sensitization (time 0) to end of visit (~8 hours)	The individual symptom score for Runny Nose was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Runny Nose symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.
Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	From time of sensitization (time 0) to end of visit (~8 hours)	The individual symptom score for Nasal Congestion was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Nasal Congestion symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.
Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	From time of sensitization (time 0) to end of visit (~8 hours)	The individual symptom score for Itchy Mouth/Throat/Ears was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Itchy Mouth/Throat/Ears symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.
Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	From time of sensitization (time 0) to end of visit (~8 hours)	The individual symptom score for Itchy Eyes was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Itchy Eyes symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.

Participant flow

Participants by arm

Arm	Count
Loratadine Participants received one dose of loratadine following randomization at 120 minutes of exposure during visit 4.	85
Fexofenadine Participants received one dose of fexofenadine following randomization at 120 minutes of exposure during visit 4.	85
Placebo Participants received one dose of placebo following randomization at 120 minutes of exposure during visit 4.	85
Total	255

Baseline characteristics

Characteristic	Loratadine	Fexofenadine	Placebo	Total
Age, Continuous	41.5 years STANDARD_DEVIATION 13.52	43.1 years STANDARD_DEVIATION 12.21	40.6 years STANDARD_DEVIATION 12.56	41.7 years STANDARD_DEVIATION 12.77
Sex: Female, Male Female	51 Participants	53 Participants	53 Participants	157 Participants
Sex: Female, Male Male	34 Participants	32 Participants	32 Participants	98 Participants

Adverse events

Event type	EG000 affected / at risk	EG001 affected / at risk	EG002 affected / at risk
deaths Total, all-cause mortality	— / —	— / —	— / —
other Total, other adverse events	0 / 85	0 / 85	0 / 85
serious Total, serious adverse events	0 / 85	0 / 85	0 / 85

Outcome results

Primary

Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)

The MSC Score is calculated as the sum of 5 individual symptom scores for Runny Nose, Itchy Nose, Sneezing, Watery Eyes, and Itchy Eyes. Each individual symptom is rated on a 5-point scale of severity: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The total MSC score ranges from 0 - 25. Increasing scores are associated with increasing severity.

Time frame: From time of sensitization (time 0) to end of visit (~8 hours)

Population: Participants in the Intent-to-Treat (ITT) Population (defined as all participants who successfully exhibited appropriate sensitivity and were randomized to study treatment) who had data available.~N=Number of Participants Analyzed, n=number of participants with data available at the given time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	225 minutes (n=85, n=85, n=85)	7.4 units on a scale	Standard Deviation 4.63
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	300 minutes (n=84, n=85, n=85)	7.1 units on a scale	Standard Deviation 4.54
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	255 minutes (n=85, n=85, n=85)	7.1 units on a scale	Standard Deviation 4.78
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	240 minutes (n=84, n=85, n=85)	7.4 units on a scale	Standard Deviation 4.76
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	180 minutes (n=85, n=85, n=85)	7.4 units on a scale	Standard Deviation 4.51
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	285 minutes (n=85, n=85, n=85)	7.3 units on a scale	Standard Deviation 4.52
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	210 minutes (n=85, n=85, n=85)	7.3 units on a scale	Standard Deviation 4.73
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	195 minutes (n=85, n=85, n=85)	7.5 units on a scale	Standard Deviation 4.84
Loratadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	270 minutes (n=85, n=85, n=85)	7.0 units on a scale	Standard Deviation 4.67
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	240 minutes (n=84, n=85, n=85)	6.5 units on a scale	Standard Deviation 4.43
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	180 minutes (n=85, n=85, n=85)	6.7 units on a scale	Standard Deviation 4.86
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	195 minutes (n=85, n=85, n=85)	6.7 units on a scale	Standard Deviation 4.87
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	210 minutes (n=85, n=85, n=85)	6.5 units on a scale	Standard Deviation 4.87
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	225 minutes (n=85, n=85, n=85)	6.5 units on a scale	Standard Deviation 4.7
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	255 minutes (n=85, n=85, n=85)	6.3 units on a scale	Standard Deviation 4.47
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	270 minutes (n=85, n=85, n=85)	6.4 units on a scale	Standard Deviation 4.5
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	285 minutes (n=85, n=85, n=85)	6.9 units on a scale	Standard Deviation 4.76
Fexofenadine	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	300 minutes (n=84, n=85, n=85)	6.5 units on a scale	Standard Deviation 4.65
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	210 minutes (n=85, n=85, n=85)	8.7 units on a scale	Standard Deviation 5.28
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	180 minutes (n=85, n=85, n=85)	8.5 units on a scale	Standard Deviation 5.07
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	270 minutes (n=85, n=85, n=85)	8.4 units on a scale	Standard Deviation 5.56
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	195 minutes (n=85, n=85, n=85)	8.9 units on a scale	Standard Deviation 5.31
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	300 minutes (n=84, n=85, n=85)	8.4 units on a scale	Standard Deviation 5.58
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	240 minutes (n=84, n=85, n=85)	8.3 units on a scale	Standard Deviation 5.38
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	225 minutes (n=85, n=85, n=85)	8.5 units on a scale	Standard Deviation 5.36
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	285 minutes (n=85, n=85, n=85)	8.7 units on a scale	Standard Deviation 5.76
Placebo	Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)	255 minutes (n=85, n=85, n=85)	8.4 units on a scale	Standard Deviation 5.51

Secondary

Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point

The individual symptom score for Itchy Nose was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Itchy Nose symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.

Time frame: From time of sensitization (time 0) to end of visit (~8 hours)

Arm	Measure	Group	Value (MEAN)	Dispersion
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	255 minutes	1.8 units on a scale	Standard Deviation 1.24
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	90 minutes	2.3 units on a scale	Standard Deviation 1.1
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	75 minutes	2.4 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	225 minutes	1.9 units on a scale	Standard Deviation 1.18
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	120 minutes	1.9 units on a scale	Standard Deviation 1.14
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	150 minutes	2.1 units on a scale	Standard Deviation 1.06
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	105 minutes	2.2 units on a scale	Standard Deviation 1.08
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	270 minutes	1.9 units on a scale	Standard Deviation 1.18
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	165 minutes	2.0 units on a scale	Standard Deviation 1.09
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	210 minutes	2.0 units on a scale	Standard Deviation 1.25
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	30 minutes	2.8 units on a scale	Standard Deviation 0.97
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	180 minutes	2.0 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	285 minutes	1.9 units on a scale	Standard Deviation 1.17
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	135 minutes	2.0 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	315 minutes	1.8 units on a scale	Standard Deviation 1.26
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	240 minutes	1.9 units on a scale	Standard Deviation 1.14
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	195 minutes	1.9 units on a scale	Standard Deviation 1.23
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	330 minutes	1.8 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	300 minutes	1.8 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	0 minutes	3.3 units on a scale	Standard Deviation 0.74
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	345 minutes	1.9 units on a scale	Standard Deviation 1.23
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	45 minutes	2.7 units on a scale	Standard Deviation 1.02
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	60 minutes	2.6 units on a scale	Standard Deviation 1.09
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	360 minutes	1.8 units on a scale	Standard Deviation 1.22
Loratadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	15 minutes	3.1 units on a scale	Standard Deviation 0.84
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	360 minutes	1.8 units on a scale	Standard Deviation 1.32
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	195 minutes	1.7 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	15 minutes	3.2 units on a scale	Standard Deviation 0.81
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	210 minutes	1.7 units on a scale	Standard Deviation 1.28
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	225 minutes	1.7 units on a scale	Standard Deviation 1.27
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	240 minutes	1.7 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	30 minutes	2.8 units on a scale	Standard Deviation 0.97
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	255 minutes	1.7 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	270 minutes	1.7 units on a scale	Standard Deviation 1.25
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	45 minutes	2.6 units on a scale	Standard Deviation 0.96
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	285 minutes	1.8 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	105 minutes	2.1 units on a scale	Standard Deviation 1.1
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	300 minutes	1.8 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	60 minutes	2.4 units on a scale	Standard Deviation 1.05
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	75 minutes	2.3 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	150 minutes	1.8 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	120 minutes	1.8 units on a scale	Standard Deviation 1.12
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	165 minutes	1.7 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	90 minutes	2.1 units on a scale	Standard Deviation 1.07
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	180 minutes	1.8 units on a scale	Standard Deviation 1.25
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	315 minutes	1.8 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	135 minutes	1.8 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	330 minutes	1.7 units on a scale	Standard Deviation 1.25
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	345 minutes	1.7 units on a scale	Standard Deviation 1.29
Fexofenadine	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	0 minutes	3.3 units on a scale	Standard Deviation 0.73
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	300 minutes	2.1 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	135 minutes	2.2 units on a scale	Standard Deviation 1.22
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	90 minutes	2.4 units on a scale	Standard Deviation 1.17
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	105 minutes	2.4 units on a scale	Standard Deviation 1.1
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	120 minutes	2.1 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	15 minutes	3.1 units on a scale	Standard Deviation 0.93
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	30 minutes	2.8 units on a scale	Standard Deviation 0.99
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	45 minutes	2.8 units on a scale	Standard Deviation 1.04
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	60 minutes	2.6 units on a scale	Standard Deviation 1.07
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	75 minutes	2.5 units on a scale	Standard Deviation 1.19
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	150 minutes	2.2 units on a scale	Standard Deviation 1.18
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	165 minutes	2.2 units on a scale	Standard Deviation 1.14
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	180 minutes	2.2 units on a scale	Standard Deviation 1.12
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	315 minutes	2.2 units on a scale	Standard Deviation 1.38
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	330 minutes	2.1 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	345 minutes	2.2 units on a scale	Standard Deviation 1.36
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	360 minutes	2.2 units on a scale	Standard Deviation 1.38
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	195 minutes	2.2 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	210 minutes	2.2 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	225 minutes	2.2 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	240 minutes	2.2 units on a scale	Standard Deviation 1.24
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	255 minutes	2.2 units on a scale	Standard Deviation 1.3
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	270 minutes	2.1 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	285 minutes	2.2 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point	0 minutes	3.4 units on a scale	Standard Deviation 0.77

Secondary

Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point

The individual symptom score for Runny Nose was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Runny Nose symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.

Time frame: From time of sensitization (time 0) to end of visit (~8 hours)

Arm	Measure	Group	Value (MEAN)	Dispersion
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	90 minutes	2.4 units on a scale	Standard Deviation 1.04
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	315 minutes	2.1 units on a scale	Standard Deviation 1.25
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	210 minutes	2.0 units on a scale	Standard Deviation 1.23
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	105 minutes	2.4 units on a scale	Standard Deviation 1.1
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	15 minutes	3.1 units on a scale	Standard Deviation 0.85
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	195 minutes	2.1 units on a scale	Standard Deviation 1.27
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	120 minutes	2.1 units on a scale	Standard Deviation 1.07
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	330 minutes	2.2 units on a scale	Standard Deviation 1.26
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	180 minutes	2.1 units on a scale	Standard Deviation 1.2
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	135 minutes	2.2 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	300 minutes	2.0 units on a scale	Standard Deviation 1.26
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	165 minutes	2.2 units on a scale	Standard Deviation 1.07
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	150 minutes	2.3 units on a scale	Standard Deviation 1.1
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	30 minutes	3.0 units on a scale	Standard Deviation 0.95
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	345 minutes	2.1 units on a scale	Standard Deviation 1.27
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	270 minutes	1.9 units on a scale	Standard Deviation 1.3
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	45 minutes	2.8 units on a scale	Standard Deviation 0.99
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	285 minutes	2.1 units on a scale	Standard Deviation 1.24
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	255 minutes	2.0 units on a scale	Standard Deviation 1.3
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	60 minutes	2.7 units on a scale	Standard Deviation 1.06
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	0 minutes	3.4 units on a scale	Standard Deviation 0.77
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	240 minutes	2.0 units on a scale	Standard Deviation 1.23
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	75 minutes	2.6 units on a scale	Standard Deviation 1.06
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	360 minutes	2.1 units on a scale	Standard Deviation 1.29
Loratadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	225 minutes	2.1 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	240 minutes	1.8 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	315 minutes	1.8 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	345 minutes	1.8 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	0 minutes	3.2 units on a scale	Standard Deviation 0.78
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	15 minutes	3.0 units on a scale	Standard Deviation 0.91
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	30 minutes	2.9 units on a scale	Standard Deviation 0.99
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	45 minutes	2.6 units on a scale	Standard Deviation 1.05
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	60 minutes	2.3 units on a scale	Standard Deviation 1.02
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	75 minutes	2.2 units on a scale	Standard Deviation 1.08
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	90 minutes	2.1 units on a scale	Standard Deviation 1.08
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	105 minutes	2.1 units on a scale	Standard Deviation 1.03
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	120 minutes	2.0 units on a scale	Standard Deviation 1
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	135 minutes	2.0 units on a scale	Standard Deviation 1.07
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	150 minutes	2.0 units on a scale	Standard Deviation 1.07
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	165 minutes	1.8 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	180 minutes	1.9 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	195 minutes	1.9 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	210 minutes	1.8 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	225 minutes	1.8 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	255 minutes	1.7 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	270 minutes	1.8 units on a scale	Standard Deviation 1.1
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	285 minutes	1.9 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	300 minutes	1.8 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	330 minutes	1.8 units on a scale	Standard Deviation 1.18
Fexofenadine	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	360 minutes	1.9 units on a scale	Standard Deviation 1.23
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	300 minutes	2.3 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	210 minutes	2.3 units on a scale	Standard Deviation 1.24
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	75 minutes	2.6 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	0 minutes	3.3 units on a scale	Standard Deviation 0.89
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	225 minutes	2.3 units on a scale	Standard Deviation 1.19
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	60 minutes	2.7 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	270 minutes	2.3 units on a scale	Standard Deviation 1.35
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	240 minutes	2.2 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	45 minutes	2.8 units on a scale	Standard Deviation 1.15
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	360 minutes	2.3 units on a scale	Standard Deviation 1.33
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	255 minutes	2.3 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	30 minutes	2.9 units on a scale	Standard Deviation 1.14
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	330 minutes	2.3 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	345 minutes	2.4 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	150 minutes	2.4 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	135 minutes	2.4 units on a scale	Standard Deviation 1.19
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	285 minutes	2.3 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	165 minutes	2.3 units on a scale	Standard Deviation 1.18
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	120 minutes	2.3 units on a scale	Standard Deviation 1.18
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	15 minutes	3.0 units on a scale	Standard Deviation 1.09
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	180 minutes	2.3 units on a scale	Standard Deviation 1.17
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	105 minutes	2.5 units on a scale	Standard Deviation 1.16
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	315 minutes	2.4 units on a scale	Standard Deviation 1.3
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	195 minutes	2.4 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point	90 minutes	2.4 units on a scale	Standard Deviation 1.28

Secondary

Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point

The individual symptom score for Itchy Eyes was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Itchy Eyes symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.

Time frame: From time of sensitization (time 0) to end of visit (~8 hours)

Arm	Measure	Group	Value (MEAN)	Dispersion
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.21
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.15
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	1.9 units on a scale	Standard Deviation 1.14
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	3.0 units on a scale	Standard Deviation 0.93
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.11
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.21
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	2.2 units on a scale	Standard Deviation 1.14
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.11
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.18
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.34
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.15
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.13
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.23
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.14
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.09
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.06
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=84)	2.6 units on a scale	Standard Deviation 1.1
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	240 minutes (n=84, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	1.9 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	3.2 units on a scale	Standard Deviation 0.87
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=84)	3.0 units on a scale	Standard Deviation 1.02
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	2.7 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	2.3 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.18
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.13
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.18
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	240 minutes (n=84, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.11
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.18
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.27
Fexofenadine	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	3.1 units on a scale	Standard Deviation 1.08
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.38
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.3
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.3
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=84)	2.8 units on a scale	Standard Deviation 1.15
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.42
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.37
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	1.9 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.33
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	1.9 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	240 minutes (n=84, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.23
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	2.2 units on a scale	Standard Deviation 1.23
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.38
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.3
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.24
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.36
Placebo	Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.26

Secondary

Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point

The individual symptom score for Itchy Mouth/Throat/Ears was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Itchy Mouth/Throat/Ears symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.

Time frame: From time of sensitization (time 0) to end of visit (~8 hours)

Arm	Measure	Group	Value (MEAN)	Dispersion
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	3.0 units on a scale	Standard Deviation 1.11
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.18
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.2
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.17
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	3.0 units on a scale	Standard Deviation 1.08
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.21
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.18
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	2.3 units on a scale	Standard Deviation 1.13
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.17
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	2.3 units on a scale	Standard Deviation 1.29
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.21
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.2
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	2.3 units on a scale	Standard Deviation 1.2
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.25
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.14
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	2.8 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.22
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	3.2 units on a scale	Standard Deviation 1.05
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.2
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	2.7 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=84)	2.3 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	1.9 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	3.0 units on a scale	Standard Deviation 1.05
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	3.0 units on a scale	Standard Deviation 1.06
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	2.8 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	2.8 units on a scale	Standard Deviation 1.09
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.27
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.16
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	2.3 units on a scale	Standard Deviation 1.16
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	2.3 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	2.2 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.12
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=84)	2.0 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.16
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.26
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.23
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.25
Fexofenadine	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.21
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.14
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	2.9 units on a scale	Standard Deviation 1.17
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=84)	2.4 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	2.3 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.23
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	2.8 units on a scale	Standard Deviation 1.12
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	3.0 units on a scale	Standard Deviation 1.09
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.7 units on a scale	Standard Deviation 1.27
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	2.8 units on a scale	Standard Deviation 1.06
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.26
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.3
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.9 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.9 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.24
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	2.3 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.27

Secondary

Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point

The individual symptom score for Nasal Congestion was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Nasal Congestion symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.

Time frame: From time of sensitization (time 0) to end of visit (~8 hours)

Arm	Measure	Group	Value (MEAN)	Dispersion
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.31
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.26
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.29
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.33
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=84)	2.4 units on a scale	Standard Deviation 1.26
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.21
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.29
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=84)	1.6 units on a scale	Standard Deviation 1.29
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.22
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.31
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.31
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.31
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.26
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.29
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.2
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.31
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.25
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.24
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.31
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	1.6 units on a scale	Standard Deviation 1.27
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	3.4 units on a scale	Standard Deviation 0.81
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.28
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	2.4 units on a scale	Standard Deviation 1.24
Loratadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	3.2 units on a scale	Standard Deviation 0.88
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	2.2 units on a scale	Standard Deviation 1.25
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.21
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=84)	2.0 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=84)	1.3 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.25
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.24
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.31
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	1.4 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	2.1 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.24
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.24
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.39
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.9 units on a scale	Standard Deviation 1.51
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	2.7 units on a scale	Standard Deviation 1.19
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.34
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.26
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.34
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.22
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.34
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=84)	1.8 units on a scale	Standard Deviation 1.46
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	300 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.43
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=84)	2.6 units on a scale	Standard Deviation 1.3
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.33
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	315 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.39
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	2.6 units on a scale	Standard Deviation 1.24
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	2.0 units on a scale	Standard Deviation 1.26
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.47
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	1.8 units on a scale	Standard Deviation 1.34
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	3.4 units on a scale	Standard Deviation 0.76
Placebo	Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point	345 minutes (n=85, n=85, n=85)	2.5 units on a scale	Standard Deviation 1.33

Secondary

Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point

The individual symptom score for Sneezing was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Sneezing symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.

Time frame: From time of sensitization (time 0) to end of visit (~8 hours)

Arm	Measure	Group	Value (MEAN)	Dispersion
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	345 minutes (n=84, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.09
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.07
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.25
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	0.8 units on a scale	Standard Deviation 1.11
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	1.1 units on a scale	Standard Deviation 1.21
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.37
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.13
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.29
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	1.2 units on a scale	Standard Deviation 1.31
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	0.8 units on a scale	Standard Deviation 1.19
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	1.2 units on a scale	Standard Deviation 1.34
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	0.9 units on a scale	Standard Deviation 1.22
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	0.8 units on a scale	Standard Deviation 1.08
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.09
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	0.8 units on a scale	Standard Deviation 1.13
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	300 minutes (n=84, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.02
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.04
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	0.5 units on a scale	Standard Deviation 0.88
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	315 minutes (n=84, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.1
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.08
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	0.8 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.02
Loratadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	300 minutes (n=84, n=85, n=85)	0.5 units on a scale	Standard Deviation 0.95
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 0.93
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	0.5 units on a scale	Standard Deviation 1.04
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=85)	0.4 units on a scale	Standard Deviation 0.86
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	0.5 units on a scale	Standard Deviation 1
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.07
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	0.5 units on a scale	Standard Deviation 1.03
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	315 minutes (n=84, n=85, n=85)	0.4 units on a scale	Standard Deviation 0.94
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.03
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	345 minutes (n=84, n=85, n=85)	0.6 units on a scale	Standard Deviation 0.99
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.09
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	1.2 units on a scale	Standard Deviation 1.36
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	1.2 units on a scale	Standard Deviation 1.39
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	1.1 units on a scale	Standard Deviation 1.32
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	0.9 units on a scale	Standard Deviation 1.22
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.12
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	0.8 units on a scale	Standard Deviation 1.16
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.07
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.07
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	0.5 units on a scale	Standard Deviation 1.04
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	0.7 units on a scale	Standard Deviation 1.2
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	0.5 units on a scale	Standard Deviation 1.03
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.11
Fexofenadine	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	0.6 units on a scale	Standard Deviation 1.09
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	330 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.38
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	165 minutes (n=85, n=85, n=85)	0.9 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	90 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.37
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	315 minutes (n=84, n=85, n=85)	1.1 units on a scale	Standard Deviation 1.4
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	240 minutes (n=85, n=85, n=85)	0.9 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	105 minutes (n=85, n=85, n=85)	1.1 units on a scale	Standard Deviation 1.43
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	300 minutes (n=84, n=85, n=85)	0.9 units on a scale	Standard Deviation 1.34
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	195 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.38
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	120 minutes (n=85, n=85, n=85)	0.9 units on a scale	Standard Deviation 1.28
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	285 minutes (n=85, n=85, n=85)	1.1 units on a scale	Standard Deviation 1.42
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	180 minutes (n=85, n=85, n=85)	0.9 units on a scale	Standard Deviation 1.3
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	135 minutes (n=85, n=85, n=85)	1.2 units on a scale	Standard Deviation 1.48
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	270 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.4
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	15 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.37
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	225 minutes (n=85, n=85, n=85)	0.9 units on a scale	Standard Deviation 1.33
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	30 minutes (n=85, n=85, n=85)	1.2 units on a scale	Standard Deviation 1.38
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	0 minutes (n=85, n=85, n=85)	1.5 units on a scale	Standard Deviation 1.4
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	150 minutes (n=85, n=85, n=85)	1.1 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	45 minutes (n=85, n=85, n=85)	1.3 units on a scale	Standard Deviation 1.39
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	360 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.38
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	255 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.41
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	60 minutes (n=85, n=85, n=85)	1.2 units on a scale	Standard Deviation 1.36
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	345 minutes (n=84, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.33
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	210 minutes (n=85, n=85, n=85)	1.0 units on a scale	Standard Deviation 1.31
Placebo	Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point	75 minutes (n=85, n=85, n=85)	1.1 units on a scale	Standard Deviation 1.39

Secondary

Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point

The individual symptom score for Water Eyes was rated on a 5-point scale of severity using the following scale: 0 = None (No symptoms), 1 = MILD (Symptom is present, but easily tolerated), 2 = MODERATE (Awareness of symptoms, bothersome, but tolerable), 3 = SEVERE (Definite awareness of symptoms, difficult to tolerate but does not interfere with activities), 4 = VERY SEVERE (Difficult to tolerate and interferes with the activities of daily living). The Watery Eyes symptom score ranges from 0 - 5. Increasing scores are associated with increasing severity.

Time frame: From time of sensitization (time 0) to end of visit (~8 hours)

Arm	Measure	Group	Value (MEAN)	Dispersion
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	360 minutes	1.2 units on a scale	Standard Deviation 1.2
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	330 minutes	1.3 units on a scale	Standard Deviation 1.14
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	285 minutes	1.2 units on a scale	Standard Deviation 1.08
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	345 minutes	1.2 units on a scale	Standard Deviation 1.15
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	150 minutes	1.2 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	255 minutes	1.2 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	315 minutes	1.2 units on a scale	Standard Deviation 1.09
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	105 minutes	1.5 units on a scale	Standard Deviation 1.22
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	15 minutes	2.4 units on a scale	Standard Deviation 1.17
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	270 minutes	1.2 units on a scale	Standard Deviation 1.13
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	90 minutes	1.5 units on a scale	Standard Deviation 1.29
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	30 minutes	2.2 units on a scale	Standard Deviation 1.23
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	165 minutes	1.2 units on a scale	Standard Deviation 1.14
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	75 minutes	1.7 units on a scale	Standard Deviation 1.21
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	45 minutes	1.9 units on a scale	Standard Deviation 1.22
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	120 minutes	1.3 units on a scale	Standard Deviation 1.15
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	0 minutes	2.7 units on a scale	Standard Deviation 1.12
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	180 minutes	1.2 units on a scale	Standard Deviation 1.07
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	60 minutes	1.8 units on a scale	Standard Deviation 1.21
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	240 minutes	1.2 units on a scale	Standard Deviation 1.16
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	195 minutes	1.2 units on a scale	Standard Deviation 1.15
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	300 minutes	1.2 units on a scale	Standard Deviation 1.02
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	225 minutes	1.2 units on a scale	Standard Deviation 1.13
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	135 minutes	1.2 units on a scale	Standard Deviation 1.11
Loratadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	210 minutes	1.2 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	240 minutes	1.1 units on a scale	Standard Deviation 1.1
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	60 minutes	1.9 units on a scale	Standard Deviation 1.16
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	120 minutes	1.3 units on a scale	Standard Deviation 1.09
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	135 minutes	1.3 units on a scale	Standard Deviation 1.11
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	150 minutes	1.2 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	165 minutes	1.2 units on a scale	Standard Deviation 1.14
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	180 minutes	1.1 units on a scale	Standard Deviation 1.12
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	195 minutes	1.2 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	225 minutes	1.1 units on a scale	Standard Deviation 1.16
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	285 minutes	1.2 units on a scale	Standard Deviation 1.13
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	330 minutes	1.2 units on a scale	Standard Deviation 1.15
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	345 minutes	1.2 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	0 minutes	2.8 units on a scale	Standard Deviation 1.05
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	15 minutes	2.6 units on a scale	Standard Deviation 1.1
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	30 minutes	2.3 units on a scale	Standard Deviation 1.17
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	45 minutes	2.0 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	75 minutes	1.8 units on a scale	Standard Deviation 1.19
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	90 minutes	1.6 units on a scale	Standard Deviation 1.23
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	105 minutes	1.6 units on a scale	Standard Deviation 1.13
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	210 minutes	1.1 units on a scale	Standard Deviation 1.13
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	255 minutes	1.1 units on a scale	Standard Deviation 1.13
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	270 minutes	1.1 units on a scale	Standard Deviation 1.09
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	300 minutes	1.1 units on a scale	Standard Deviation 1.1
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	315 minutes	1.2 units on a scale	Standard Deviation 1.13
Fexofenadine	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	360 minutes	1.3 units on a scale	Standard Deviation 1.17
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	345 minutes	1.4 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	225 minutes	1.4 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	360 minutes	1.4 units on a scale	Standard Deviation 1.34
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	210 minutes	1.4 units on a scale	Standard Deviation 1.27
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	195 minutes	1.5 units on a scale	Standard Deviation 1.21
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	180 minutes	1.3 units on a scale	Standard Deviation 1.16
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	165 minutes	1.4 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	240 minutes	1.4 units on a scale	Standard Deviation 1.24
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	315 minutes	1.4 units on a scale	Standard Deviation 1.33
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	255 minutes	1.4 units on a scale	Standard Deviation 1.26
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	150 minutes	1.4 units on a scale	Standard Deviation 1.2
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	330 minutes	1.4 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	270 minutes	1.4 units on a scale	Standard Deviation 1.21
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	135 minutes	1.4 units on a scale	Standard Deviation 1.29
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	285 minutes	1.4 units on a scale	Standard Deviation 1.27
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	120 minutes	1.4 units on a scale	Standard Deviation 1.18
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	45 minutes	2.0 units on a scale	Standard Deviation 1.18
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	30 minutes	2.1 units on a scale	Standard Deviation 1.25
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	60 minutes	1.9 units on a scale	Standard Deviation 1.12
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	75 minutes	1.6 units on a scale	Standard Deviation 1.11
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	15 minutes	2.4 units on a scale	Standard Deviation 1.15
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	300 minutes	1.3 units on a scale	Standard Deviation 1.32
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	90 minutes	1.5 units on a scale	Standard Deviation 1.18
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	0 minutes	2.7 units on a scale	Standard Deviation 1.02
Placebo	Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point	105 minutes	1.5 units on a scale	Standard Deviation 1.19

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026

A Study of Onset of Action of Loratadine and Fexofenadine in Participants With Seasonal Allergic Rhinitis (P08712)

Conditions

Brief summary

Related papers

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Study design

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Design outcomes

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Secondary

Participant flow

Participants by arm

Baseline characteristics

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Outcome results

Mean Major Symptom Complex (MSC) Score by Post-Treatment Evaluation Time Point (From 180 Minutes to 300 Minutes)

Mean Individual Symptom Score for Itchy Nose by Post-Treatment Evaluation Time Point

Mean Individual Symptom Score for Runny Nose by Post-Treatment Evaluation Time Point

Mean Individual Symptom Scores for Itchy Eyes by Post-Treatment Evaluation Time Point

Mean Individual Symptom Scores for Itchy Mouth/Throat/Ears by Post-Treatment Evaluation Time Point

Mean Individual Symptom Scores for Nasal Congestion by Post-Treatment Evaluation Time Point

Mean Individual Symptom Scores for Sneezing by Post-Treatment Evaluation Time Point

Mean Individual Symptom Scores for Watery Eyes by Post-Treatment Evaluation Time Point