Type 2 Diabetes
Conditions
Keywords
Diabetes
Brief summary
The investigators hypothesis is that a carbohydrate-free diet, ingested for 3 days, results in a change in blood glucose that is similar to the change observed after 3 days of fasting.
Detailed description
In addition to plasma glucose concentrations, other hormones and metabolites known to be affected by fasting will be measured. These include insulin and glucagon, which are hormones that have an important role in regulating fuel use in the body.
Interventions
OTHER3 day fast
Subjects will fast for 72 hours
OTHER3 day CHO-free diet
Subjects will receive a carbohydrate-free diet for 72 hours
Sponsors
Minneapolis Veterans Affairs Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes * C-peptide \> 1.5 ng/ml
Exclusion criteria
* Body mass index \> 40 * hematological abnormalities * liver disease * kidney disease * congestive heart failure * life threatening malignancies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in plasma glucose concentration | 24 hour profile:before and after meals, or traditional meal times |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum insulin concentrations | 24 hour profiles: before and after meals or traditional meal times |
Countries
United States
Outcome results
None listed