The Effect of Roux-en-Y Gastric Bypass on Mitochondrial Function in Type 2 Diabetes

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01468116

Enrollment

Registered

2011-11-09

Start date

2011-03-31

Completion date

2013-12-31

Last updated

2011-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Type 2 Diabetes

Keywords

Type 2 diabetes, Gastric bypass surgery, Obesity, Mitochondrial function

Brief summary

Roux-en-Y gastric bypass (RYGB) surgery induces resolution of type 2 diabetes, often within days after surgery and before significant weight loss. The aim of this study is to investigate whether changes in mitochondrial function contributes to the early improvement of type 2 diabetes after RYGB.

Detailed description

Mitochondrial dysfunction has been linked to development of insulin resistance in the muscle and hence to the pathogenesis of type 2 diabetes. Mitochondrial function can be studied non-invasively by 31 Phosphor Magnetic Resonance spectroscopy (31PMRS). In this study we will investigate changes in mitochondrial function using the combination of 31 PMRS and Near Infra-Red Spectroscopy (NIRS) after gastric bypass.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients eligible for gastric bypass surgery or cholecystectomy * Verified type 2 diabetes or normal glucose tolerance by OGTT

Exclusion criteria

* Patients unable to fit the dimensions of the MRI-scanner

Countries

Denmark

Contacts

Primary ContactKirstine Nyvold Bojsen-Møller, MD

kirstine.bojsen-moeller@hvh.regionh.dk+4538626371

Backup ContactSten Madsbad, professor, MD

sten.madsbad@hvh.regionh.dk+4538622291

Outcome results