Brain Injury, Stroke, Vegetative State
Conditions
Keywords
Diagnosed vegetative state after stroke or traumatic brain injury
Brief summary
It has already been demonstrated that mental imagining of the complex motor act, such as limb lifting, can evoke the activation of the involved motor centres even if it doesn't result in movement due to paresis. Aim of the study: using the navigated brain stimulation system create a new diagnostic model for the differential diagnostics between the vegetative state and the minimally conscious state. If the investigators could get from patient the efferent motor response after a verbal command, his level of conscious should not be defined less than the minimally conscious state.
Interventions
DEVICENavigated transcranial magnetic brain stimulation
Standard NBS motor mapping using the Eximia TMS stimulator, Nexstim Ltd., Finland.
Sponsors
City Hospital No 41, Ekaterinburg, Russia
Clinical Institute of the Brain, Russia
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* diagnosed vegetative state * age 20-85
Exclusion criteria
* oncological history * cardiac pacemakers and other metal implants * Modified Ashford Scale scores 3 and more * predisposing disease with motor neurologic impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MEP(motor evoked potential) parameter: latency | within the first minute after a verbal command |
Secondary
| Measure | Time frame |
|---|---|
| MEP(motor evoked potential) parameter: amplitude | within the first minute after a verbal command |
| MEP(motor evoked potential) parameter: motor threshold | within the first minute after a verbal command |
| conscious state | within the first 6 months after NBS mapping |
Countries
Russia
Outcome results
None listed