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Metacarpophalangeal Joint Reconstruction Using a Vascularized Cartilage and Bone Graft

Phase 1 Study for Reconstruction of Metacarpophalangeal Joint Using a Vascularized Cartilage and Bone Graft From the Third Metacarpal

Status
Completed
Phases
Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01467752
Acronym
MJRUVCBG
Enrollment
15
Registered
2011-11-09
Start date
2005-01-31
Completion date
2009-12-31
Last updated
2011-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Volar Plate Injury, Thumb, Metacarpophalangeal Joint

Keywords

reconstruction, metacarpophalangeal joint, bone graft, MCP joint

Brief summary

Traumatic cartilage loss of the joint is central to the development of joint failure in arthritis. The study on the use of a bone graft for reconstruction of metacarpophalangeal joint defects.

Detailed description

The metacarpophalangeal joint is vital for hand function. Cartilage loss of the joint is central to the development of joint failure in arthritis. Although various treatments have been proposed, the management remains a challenging problem.Previous anatomical studies have shown that, at the base of the metacarpal, there were nutrient arteries inserting into the dorsum of the metacarpal. The nutrient arteries arise from the distal and middle dorsal carpal arches that run distally to the first to fourth dorsal metacarpal arteries (DMAs. These studies prompt us to use a reverse vascularized cartilage and bone graft based on the DMA. The metacarpal consists of a widened proximal base. The joint surface to the capitate is convex anteriorly and dorsally concave, where it extends to the styloid process on the dorsolateral aspect of the metacarpal base. The unique contour stimulates our imagination and creativity to use a portion of the joint surface for reconstruction of metacarpophalangeal joint defects. The purpose of this study is to report the novel technique and to evaluate the effectiveness of the treatment.

Interventions

PROCEDUREMCP joint

reconstruction of metacarpophalangeal (MCP) joint using a bone graft

Sponsors

The Second Hospital of Qinhuangdao
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

1. a cartilage defect at either proximal or distal MCP joint; 2. either an acute or old injury; 3. loss of 1/4 of joint entire surface that seen on plain radiographs, CT scan, and intraoperative finding; 4. and with or without MCP joint subluxation.

Exclusion criteria

1. large defects involved double joint surfaces; 2. the size of the defect involving less than 1/4 of the joint surface; 3. associate with infection or other diseases that restrict to use the technique.

Design outcomes

Primary

MeasureTime frameDescription
Range of motion; Arm, Shoulder and Hand questionnaire4 yearsThe active motions of the hand were measured by a goniometer. The patients rated their MCP joint pain, the donor joint pain, and scar pain using a line by a visual analogue scale (VAS). We used the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire to assess the hand function.

Secondary

MeasureTime frameDescription
Pain4 yearsjoint pain is assessed using visual analogue scale

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026