Pain
Conditions
Keywords
Hysterectomy, Pain, Pregabalin
Brief summary
Pregabalin will decrease the total amount of opioid required in patients undergoing total abdominal hysterectomy. In addition, pregabalin will decrease the incidence of opioid-related side effects in patients undergoing total abdominal hysterectomy.
Interventions
DRUGPlacebo administration
Administration of placebo
DRUGPregabalin administration
Administration of pregabalin
Sponsors
Northwestern University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* ASA Physical Status 1-2 * Age 18-64 * BMI 18-35 * Scheduled for elective total abdominal hysterectomy (with or without bilateral salpingo-oophorectomy) * Gender: Female * Consent: Obtained
Exclusion criteria
* Patient refusal * Allergy to study medication(s) * Preoperative use of gabapentinoids * Preoperative use of anticonvulsants * Daily use of analgesics * Hepatic disease * Renal insufficiency (Cr \>2.0) * Alcohol or drug abuse * Pregnancy * Language: Non-English speaking * Patient expected to remain intubated after procedure Dropout: * Patient request * Surgeon request * Allergic reaction to pregabalin * Surgical procedure significantly altered from scheduled procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total hydromorphone consumption | 24 hours | total hydromorphone consumption 24 hours post operatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain Scores postoperative | Post operative period | Post operative pain scores |
Outcome results
None listed