The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients

Diagnostic Accuracy of Pancreatic Stone Protein in Predicting Severe Outcome in Patients With Peritonitis at the Intensive Care Unit

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01465711

Enrollment

137

Registered

2011-11-07

Start date

2007-07-31

Completion date

2014-12-31

Last updated

2014-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Death, Multiple Organ Failure, Peritonitis, Sepsis

Keywords

Peritonitis, Sepsis, General Surgery, Intensive Care Units, Sensitivity and Specificity

Brief summary

The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with other blood parameters, including C-Reactive Protein (CRP), White Cell Count (WCC), Interleucin-6 (IL-6) and Procalcitonin (PCT).

Detailed description

Peritonitis is a severe complication after abdominal surgery. Patients admitted at the Intensive Care Unit (ICU) following surgery bear the risk of localized infection, sepsis or septic shock. Prevention or early detection of such events is important to intervene with an appropriate therapeutic action and avoid risking a potentially life-threatening situation. White blood cell counts (WCC) and C-Reactive Protein (CRP), Interleucin-6 (IL-6) and Procalcitonin (PCT) have all been promising parameters, however, they are useful only in selective cases and have a limited diagnostic accuracy.

Interventions

PROCEDUREAll abdominal surgical procedures

Laparotomy, Laparoscopy

PROCEDUREIntubation

Ventilatory support

RADIATIONImaging

Abdominal ultrasound Computer Tomography Magnetic Resonance Imaging

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Abdominal surgery. * Admission to the Intensive Care Unit (ICU). * Blood sampling within 3 hours from admission to the ICU * Patient over 18 years of age

Exclusion criteria

* Patients already treated for peritonitis. * Patients referred from other hospitals with suspicion of peritonitis * Patient age less than 18 years of age.

Design outcomes

Primary

Measure	Time frame	Description
Localization of Peritonitis	up to 2 months	Localised vs. diffused. A clinical finding intra-operatively and/or radiologically (i.e. CT or MRI)

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 23, 2026