Treatment of APAP Toxicity With IV and Oral NAC 2008-2011

Treatment of Acetaminophen Toxicity With Intravenous vs. Oral N-acetylcysteine: A Retrospective Review

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01465542

Enrollment

Registered

2011-11-04

Start date

2011-06-30

Completion date

2011-11-30

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acetaminophen Toxicity

Keywords

Acetaminophen Toxicity, Acetaminophen Overdose, N-acetylcysteine, Liver Toxicity

Brief summary

Retrospective chart review of patients who receive N-acetylcysteine for Acetaminophen(APAP) toxicity to assess length of oral vs. IV treatment and the effect of a Clinical Pharmacology and Toxicology division in the management of APAP ingestions.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Months to 21 Years

Healthy volunteers

Inclusion criteria

* Admitted to CHMCA between June 1, 2008 to June 30, 2011 * Qualifying ICD-9 diagnosis code for the following APAP overdose situations: poisoning, accidental, suicide attempt, therapeutic use, assault, and undetermined (965.4, E850.4, E950.0, E935.4, E962.0, E980.0) * Serum APAP concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained \> 4 hours post ingestion * Between ages 0-21 years on date of admission * Acute APAP ingestion

Exclusion criteria

* Serum APAP concentrations not actually documented * Did not receive the oral or IV NAC treatment * Preexisting liver disease such as cirrhosis or hepatitis C * Patient \> 21 years of age on the date of admission * Chronic APAP ingestion

Design outcomes

Primary

Measure	Time frame	Description
Length of NAC treatment in hours	Retrospective data collection for patient's hospital admission, max estimated 5days	Length of NAC treatment (in hours) for both IV and PO formulations used in patients with APAP toxicity

Secondary

Measure	Time frame	Description
Pharmacology & Toxicology consults	Retrospective data collection for length of patient's hospital admission, max estimated 5 days	Documenting whether or not a pharmacology & toxicology consult was obtained during the patient's hospital admission for APAP toxicity

Countries

United States

Outcome results