Imagery Rescripting in the Treatment of Post Traumatic Stress Disorder (PTSD) Following Early Chronic Interpersonal Trauma

Rescripting With vs. Without Prior Stabilization in PTSD Following Early Chronic Interpersonal Trauma

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01464892

Enrollment

Registered

2011-11-04

Start date

2011-10-31

Completion date

2017-10-31

Last updated

2021-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Posttraumatic Stress Disorder (PTSD)

Keywords

Imagery rescripting, Imagery rescripting and reprocessing therapy, Skills Training in affective and interpersonal regulation, Post-traumatic Stress Disorder, Childhood abuse, Childhood sexual abuse

Brief summary

Imagery Rescripting (IR)is a promising treatment for PTSD in adult survivors of early, chronic, interpersonal trauma (e.g. Smucker & Dancu, 1999). So far, this protocol has not been investigated within a controlled setting with patients with PTSD following early, chronic, interpersonal trauma. The aim of the proposed study is to 1. investigate the efficacy of Imagery Rescripting and 2. check whether the efficacy of Imagery Rescripting can be improved by adding a stabilization phase (Skills training in affective and interpersonal regulation, STAIR) prior to this treatment. In a randomized controlled trial three conditions will be compared: 1. Imagery Rescripting 2. STAIR + Imagery Rescripting 3. Wait-list control

Interventions

BEHAVIORALImagery Rescripting and Reprocessing Therapy

This intervention is comprised of 16 sessions (twice a week) of trauma-focused imagery rescripting

BEHAVIORALSTAIR + Imagery Rescripting

A two-phased treatment. Phase 1 is comprised of 8 (weekly) sessions of Skills Training in Affective and Interpersonal Skills (STAIR). Phase 2 consists of 16 sessions (twice weekly) of trauma-focused imagery rescripting.

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* a full diagnosis of post-traumatic stress disorder (PTSD) according to DSM-IV * having experienced repeated or chronic interpersonal trauma by care-takers or authority figures before the age of 15 * between the age of 18 and 65 years * sufficient fluency of Dutch to complete treatment and research-protocol * participants using prescribed anti-depressant medication are required to be on a stable dose for at least 6 weeks before the beginning of treatment and remain on this dose throughout the treatment

Exclusion criteria

* psychosis * bipolar disorder * significant cognitive impairment * substance dependence * current use of benzodiazepines * severe suicidal ideation or life-threatening automutilation * current trauma or threat * unstable living circumstances * antisocial personality disorder * primary diagnosis of borderline personality disorder

Design outcomes

Primary

Measure	Time frame	Description
Change from Baseline in Clinician-Administered PTSD Scale (CAPS) at 8 weeks	baseline and 8 weeks	comparison STAIR vs ImRs vs WL
Change from Baseline in Posttraumatic Diagnostic Scale (PDS) at 8 weeks	baseline and 8 weeks	comparison STAIR vs ImRs vs WL

Secondary

Measure	Time frame
Change from Baseline in Inventory of Interpersonal Problems (IIP)at 8 weeks	baseline and 8 weeks
Change from Baseline in Dissociation Questionnaire (DIS-Q)at 8 weeks	baseline and 8 weeks
Change from Baseline in WHO-Quality of Life(WHO-QL)at 8 weeks	baseline and 8 weeks
Change from Baseline in Difficulties in Emotion Regulation Scale (DERS)at 8 weeks	baseline and 8 weeks
Change from Baseline in Structured Clinical Interview - Axis I (SCID-1)at 8 weeks	baseline and 8 weeks
Posttreatment: Change from Baseline in Clinician-Administered PTSD Scale (CAPS)at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs 24 weeks (WL/STAIR/ImRs)	baseline and max.24 weeks (depending on condition)
12-week follow-up: Change from Baseline in Clinician-Administered PTSD Scale (CAPS) at 20 weeks (ImRs) vs 28 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR/ImRs).	baseline and max. 36 weeks (depending on condition)
Post-treatment: Change from Baseline in Posttraumatic Diagnostic Scale (PDS) at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs. 24 weeks (WL/STAIR/ImRs)	baseline and max.24 weeks (depending on condition)
12-week fu: Change from Baseline in Posttraumatic Diagnostic Scale (PDS) at 20 weeks (ImRs) vs 28 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR)./ImRs).	baseline and max. 36 weeks (depending on condition)
Post-treatment: Change from Baseline in Beck Depression Inventory (BDI) at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs. 24 weeks (WL/STAIR).	baseline and max 24 weeks (depending on condition)
Change from Baseline in Beck Depression Inventory (BDI) at 20 weeks (ImRs) vs 12-week-fu: 8 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR).	baseline and max 36 weeks (depending on condition)
Change from Baseline in Beck Depression Inventory (BDI)at 8 weeks	baseline and 8 weeks
12-week FU: Change from Baseline in Buss-Durkee Hostility Inventory (BDHI) at 20 weeks (ImRs) vs 28 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR).	baseline and max 36 weeks (depdending on condition)
Post-treatment: Change from Baseline in Inventory of Interpersonal Problems (IIP) at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs. 24 weeks (WL/STAIR).	baseline and max 24 weeks (depending on condition)
12-week FU: Change from Baseline in Inventory of Interpersonal Problems (IIP) at 20 weeks (ImRs) vs 28 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR).	baseline and max 36 weeks (depdending on condition)
Post-treatment: Change from Baseline in Dissociation Questionnaire (DIS-Q) at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs. 24 weeks (WL/STAIR)	baseline and max 24 weeks (depending on condition)
12-week FU: Change from Baseline in Dissociation Questionnaire (DIS-Q) at 20 weeks (ImRs) vs 28 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR).	baseline and max 36 weeks (depdending on condition)
Post-treatment: Change from Baseline in WHO-Quality of Life(WHO-QL) at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs. 24 weeks (WL/STAIR)	baseline and max 24 weeks (depending on condition)
12-week FU: Change from Baseline in WHO-Quality of Life(WHO-QL) at 20 weeks (ImRs) vs 28 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR).	baseline and max 36 weeks (depdending on condition)
Post-treatment: Change from Baseline in Difficulties in Emotion Regulation Scale Post-treatment: Change from Difficulties in Emotion Regulation Scale (DERS) at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs. 24 weeks (WL/STAIR)	baseline and max 24 weeks (depending on condition)
12-week FU: Change from Baseline in Difficulties in Emotion Regulation Scale (DERS) at 20 weeks (ImRs) vs 28 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR).	baseline and max 36 weeks (depdending on condition)
Post-treatment: Change from Baseline in Structured Clinical Interview - Axis I (SCID-1) at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs. 24 weeks (WL/STAIR)	baseline and max 36 weeks (depdending on condition)
12-week FU: Change from Baseline in Structured Clinical Interview - Axis I (SCID-1) at 20 weeks (ImRs) vs 28 weeks (STAIR/ImRs; WL/ImRs) vs. 36 weeks (WL/STAIR).	baseline and max 36 weeks (depdending on condition)
Post-treatment: Change from Baseline in Buss-Durkee Hostility Inventory (BDHI) at 8 weeks (ImRs) vs 16 weeks (STAIR/ImRs; WL/ImRs) vs. 24 weeks (WL/STAIR	baseline and max 24 weeks (depending on condition)
Change from Baseline in Buss-Durkee Hostility Inventory (BDHI)at 8 weeks	baseline and 8 weeks

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026