High Plasma Level of Long Pentraxin 3 is Associated With Insulin Resistance in Women With Polycystic Ovary Syndrome (PCOS)

High Plasma Level of Long Pentraxin 3 is Associated With Insulin Resistance in Women With Polycystic Ovary Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01463969

Enrollment

Registered

2011-11-02

Start date

2010-05-31

Completion date

2011-05-31

Last updated

2011-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PCOS

Keywords

PCOS and PTX3 levels

Brief summary

In the present study, serum pentraxin 3 level and its relationship with insulin resistance were determined in patients with Polycystic Ovary Syndrome (PCOS. It was found that PTX3 level is increased in patients with PCOS and it is positively correlated with HOMA-IR.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Absence of significant abnormalities on physical examination except hirsutism * No lipid lowering, hypoglycemic, antihypertensive or hormone replacement therapy * Normal thyroid function and prolactin level * Absence of history or evidence of metabolic, cardiovascular, respiratory or hepatic disease

Exclusion criteria

* Pregnant * Possible ovarian tumors, * Congenital adrenal hyperplasia or * BMI greater than 35 kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Level of of pentraxin3 in cases with Polycystic Ovarian Syndrome	1 year	Mean PTX3 was significantly higher in patients with PCOS. This means that there is increased level of inflamation in patients with PCOS.

Secondary

Measure	Time frame	Description
Relationship of PTX3 with insuline resistance in patients with PCOS.	1 year	PTX3 was positively correlated with HOMA-IR. This means that inflamation may cause insuline resistance in patients with PCOS.

Countries

Turkey (Türkiye)

Outcome results