Coronary Artery Disease
Conditions
Keywords
Coronary Artery Bypass, Off-Pump, Saline Solution, Hypertonic
Brief summary
This is a comparison between Hypertonic versus isotonic solution in a double blind randomized trial for off pump Coronary Artery Bypass Graft (CABG) surgery targeting the left marginal branch. Hypertonic solution should provide better tolerance for heart mobilization with less volume expansion and less drugs.
Interventions
Use of Hypertonic solution 4 ml/Kg during left marginal branch CABG surgery.
DRUGIsotonic
Use of Isotonic solution 4 ml/Kg during left marginal branch CABG surgery.
Sponsors
Hospital Pitangueiras
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Off pump CABG targeting the left marginal branch
Exclusion criteria
* On pump surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Use of vasoactive drugs in left marginal branch off pump CABG surgery | time related to left branch coronary anastomosis for drug need. | Comparison between hypertonic and isotonic solutions for need of vasoactive drugs with heart mobilization during left marginal branch off pump CABG surgery. Data will be collected respectively at 1, 5 and 10 minutes after beggining the left branch coronary anastomosis. Data will be type of drug need and dosage until the end os the anastomosis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fluid balance | Operative period and first operative day | Comparison of fluid balance in the operative period between hypertonic and isotonic solutions. Data will be collected at the end of surgery and by next mornning. |
Countries
Brazil
Contacts
Primary ContactRoberto R Silva, MD PHD
Outcome results
None listed