Effect of Nefopam on Acute Postoperative Pain in Patients Undergoing Orthognathic Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01461031

Enrollment

Registered

2011-10-27

Start date

2011-10-31

Completion date

2012-09-30

Last updated

2021-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthognathic Surgery, Pain

Keywords

pain, orthognathic

Brief summary

The aim of this study is to determine the analgesic effect of perioperative nefopam on acute pain in patient undergoing orthognathic surgery.

Interventions

DRUGnefopam

nefopam infusion for postoperative 24 hours

DRUGnormal saline (control)

normal saline infusion for postoperative 24 hours

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* aged 20-60 years * undergoing elective orthognathic surgery

Exclusion criteria

* pregnancy * psychiatric disease * hepatobiliary or renal disease * monoamine oxidase inhibitor-taking patients

Design outcomes

Primary

Measure	Time frame
pain score on the visual analogue scale	after orthognathic surgery (up to postoperative 24 hours)

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026