Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy and Distal Pancreatic Resection

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01460615

Enrollment

Unknown

Registered

2011-10-27

Start date

2011-02-28

Completion date

2017-01-31

Last updated

2018-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Complications, Postoperative Pancreatitis

Keywords

Postoperative pancreatitis, Postoperative complications, Delayed gastric emptying, Leakage, Fistula, Acinar cell, Risk patient, Pancreaticoduodenectomy, Whipple, Cortisone

Brief summary

The purpose of this randomized, placebo-controlled trial is to investigate whether postoperative pancreatitis and other immediate complications after pancreaticoduodenectomy or distal pancreatic resection may be reduced with cortisone treatment. Treatment is administered to high risk patients (defined by high amount of acinar cells in the cut edge of pancreas).

Interventions

DRUGHydrocortisone

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Pancreaticoduodenectomy and distal pancreatectomy patients in Tampere University Hospital

Exclusion criteria

* Patients with an ongoing cortisone treatment * Cefuroxime allergy * Chronic pancreatitis

Design outcomes

Primary

Measure	Time frame	Description
Postoperative overall complications of pancreatic resection	within the first 30 days after surgery	e.g. Postoperative pancreatic fistula, delayed gastric emptying, postpancreatectomy hemorrhage, biliary fistula, wound infection, postoperative pancreatitis.

Countries

Finland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 11, 2026